{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:22:19Z","timestamp":1756992139311},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,12,1]]},"abstract":"<jats:p>1. Plasma cortisol at 08.00 hours was significantly higher (P &amp;lt; 0.005) in patients with high-renin essential or renovascular hypertension (22.6 \u00b1 1.6 \u03bcg\/100 ml) than in patients with normal-renin (15.4 \u00b1 1.2) or low-renin (11.9 \u00b1 1.2) forms of hypertension.<\/jats:p>\n               <jats:p>2. Plasma cortisol at 12.00 or 16.00 hours did not differ significantly among the three groups; thus the diurnal swing in plasma cortisol was steepest in patients with high plasma renin.<\/jats:p>\n               <jats:p>3. Among all patients studied, there was a direct relationship between 08.00 hours plasma cortisol and ambulatory plasma renin activity (r = 0.65, P &amp;lt; 0.001).<\/jats:p>\n               <jats:p>4. In patients with high-renin values, 08.00 hours plasma cortisol fell by 39 \u00b1 6% after 10 days treatment with the converting enzyme inhibitor captopril. No consistent decreases were observed in the normal- or low-renin groups.<\/jats:p>\n               <jats:p>5. We conclude that the renin\u2014angiotensin system may interact with the pituitary\u2014adrenal axis to influence circulating levels of cortisol. This effect might conceivably contribute to the pathogenesis of certain high-renin states.<\/jats:p>","DOI":"10.1042\/cs061265s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"265s-268s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between Plasma Renin and Cortisol in Hypertensive Patients"],"prefix":"10.1042","volume":"61","author":[{"given":"S. A.","family":"Atlas","sequence":"first","affiliation":[{"name":"Cardiovascular Center and Department of Medicine, New York Hospital\u2014Cornell Medical Center, New York, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Case","sequence":"additional","affiliation":[{"name":"Cardiovascular Center and Department of Medicine, New York Hospital\u2014Cornell Medical Center, New York, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean E.","family":"Sealey","sequence":"additional","affiliation":[{"name":"Cardiovascular Center and Department of Medicine, New York Hospital\u2014Cornell Medical Center, New York, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. H.","family":"Laragh","sequence":"additional","affiliation":[{"name":"Cardiovascular Center and Department of Medicine, New York Hospital\u2014Cornell Medical Center, New York, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/265s\/876767\/cs061265s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/265s\/876767\/cs061265s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:23:09Z","timestamp":1638480189000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/s7\/265s\/102477\/Relationship-between-Plasma-Renin-and-Cortisol-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12,1]]},"references-count":0,"journal-issue":{"issue":"s7","published-print":{"date-parts":[[1981,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs061265s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1981,12,1]]}}}