{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T08:57:58Z","timestamp":1759481878072},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,12,1]]},"abstract":"<jats:p>1. The effects of the new oral angiotensin-converting enzyme (ACE) inhibitor MK-421 on blood pressure, plasma renin activity, angiotensin II, aldosterone and converting enzyme activity were assessed in 16 hypertensive patients followed for 6\u201318 weeks.<\/jats:p>\n               <jats:p>2. After an initial titration period, maintenance doses of 2.5\u201340 mg once daily produced satisfactory blood pressure control in 11 and a partial but significant decrease in the remainder.<\/jats:p>\n               <jats:p>3. Treatment was associated with no change in heart rate and no orthostatic hypotension. At 24 h after the first effective dose, blood pressure was still decreased, plasma ACE was suppressed to 16% of the baseline, plasma angiotensin to 58%, aldosterone to 42%, and plasma renin activity was elevated to 228% of the baseline.<\/jats:p>\n               <jats:p>4. Magnitude of blood pressure fall was significantly correlated with the height of pretreatment blood pressure but not with baseline levels of plasma renin activity.<\/jats:p>","DOI":"10.1042\/cs061281s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"281s-283s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effects of the Oral Angiotensin-Converting Enzyme Inhibitor MK-421 in Human Hypertension"],"prefix":"10.1042","volume":"61","author":[{"given":"H.","family":"Gavras","sequence":"first","affiliation":[{"name":"Department of Medicine, Boston University Medical Center, Thorndike Memorial Laboratories, Boston City Hospital, Boston, MA, U.S.A."},{"name":"Centre Hospitalier Universitaire, Lausanne, Switzerland"},{"name":"Merck, Sharp and Dohme, West Point, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Biollaz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Medical Center, Thorndike Memorial Laboratories, Boston City Hospital, Boston, MA, U.S.A."},{"name":"Centre Hospitalier Universitaire, Lausanne, Switzerland"},{"name":"Merck, Sharp and Dohme, West Point, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Waeber","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Medical Center, Thorndike Memorial Laboratories, Boston City Hospital, Boston, MA, U.S.A."},{"name":"Centre Hospitalier Universitaire, Lausanne, Switzerland"},{"name":"Merck, Sharp and Dohme, West Point, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. R.","family":"Brunner","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Medical Center, Thorndike Memorial Laboratories, Boston City Hospital, Boston, MA, U.S.A."},{"name":"Centre Hospitalier Universitaire, Lausanne, Switzerland"},{"name":"Merck, Sharp and Dohme, West Point, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gavras","family":"Irene","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Medical Center, Thorndike Memorial Laboratories, Boston City Hospital, Boston, MA, U.S.A."},{"name":"Centre Hospitalier Universitaire, Lausanne, Switzerland"},{"name":"Merck, Sharp and Dohme, West Point, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sackel","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Medical Center, Thorndike Memorial Laboratories, Boston City Hospital, Boston, MA, U.S.A."},{"name":"Centre Hospitalier Universitaire, Lausanne, Switzerland"},{"name":"Merck, Sharp and Dohme, West Point, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Charocopos","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Medical Center, Thorndike Memorial Laboratories, Boston City Hospital, Boston, MA, U.S.A."},{"name":"Centre Hospitalier Universitaire, Lausanne, Switzerland"},{"name":"Merck, Sharp and Dohme, West Point, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. O.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Medicine, Boston University Medical Center, Thorndike Memorial Laboratories, Boston City Hospital, Boston, MA, U.S.A."},{"name":"Centre Hospitalier Universitaire, Lausanne, Switzerland"},{"name":"Merck, Sharp and Dohme, West Point, PA, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/281s\/876835\/cs061281s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/281s\/876835\/cs061281s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:24:04Z","timestamp":1638480244000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/s7\/281s\/102588\/Effects-of-the-Oral-Angiotensin-Converting-Enzyme"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12,1]]},"references-count":0,"journal-issue":{"issue":"s7","published-print":{"date-parts":[[1981,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs061281s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1981,12,1]]}}}