{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T21:28:00Z","timestamp":1699133280380},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"s7","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1981,12,1]]},"abstract":"<jats:p>1. The role of opiates in cardiovascular regulation has been investigated.<\/jats:p>\n               <jats:p>2. In urethane-anaesthetized renal hypertensive rats (two-kidney, one-clip Goldblatt model), intracerebroventricular \u03b2-endorphin (10 \u03bcg) caused a greater fall in mean arterial pressure than in sham-operated controls.<\/jats:p>\n               <jats:p>3. Unilateral injection of \u03b2-endorphin into the nucleus tractus solitarii of the urethane-anaesthetized rat resulted in a U-shaped dose\u2014response relationship, with a fall in mean arterial pressure and heart rate occurring at low doses. Doses above 10 ng caused a rise in pressure, accompanied by a variable effect on heart rate.<\/jats:p>\n               <jats:p>4. The fall in blood pressure and heart rate was prevented by prior subcutaneous administration of naloxone. Naloxone caused an increase in blood pressure when administered alone.<\/jats:p>\n               <jats:p>5. These results suggest a depressor role of an endogenous brain opiate, possibly \u03b2-endorphin; a site of action is probably the nucleus tractus solitarii.<\/jats:p>","DOI":"10.1042\/cs061339s","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:38:55Z","timestamp":1438943935000},"page":"339s-342s","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["<i>\u03b2<\/i>-Endorphin, An Endogenous Depressor Agent in the Rat?"],"prefix":"10.1042","volume":"61","author":[{"given":"M. A.","family":"Petty","sequence":"first","affiliation":[{"name":"Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. A.","family":"Sitsen","sequence":"additional","affiliation":[{"name":"Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"De Jong","sequence":"additional","affiliation":[{"name":"Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/339s\/876623\/cs061339s.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/61\/s7\/339s\/876623\/cs061339s.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:21:19Z","timestamp":1638480079000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/61\/s7\/339s\/102288\/Endorphin-An-Endogenous-Depressor-Agent-in-the-Rat"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12,1]]},"references-count":0,"journal-issue":{"issue":"s7","published-print":{"date-parts":[[1981,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs061339s","relation":{},"ISSN":["0144-9664"],"issn-type":[{"value":"0144-9664","type":"print"}],"subject":[],"published":{"date-parts":[[1981,12,1]]}}}