{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T08:49:56Z","timestamp":1692348596403},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,1,1]]},"abstract":"<jats:p>1. The present study investigates the role of mineralocorticoids in the pathogenesis of salt retention and ascites in dogs with chronic ligation of the common bile duct (CBDL).<\/jats:p>\n               <jats:p>2. After CBDL the natriuretic response to an intravenous sodium load [0.9% sodium chloride solution (150 mmol\/l): saline; 10% of body weight] was markedly depressed. Urinary sodium excretion was 285 \u00b1 62 vs 960 \u00b1 58 \u03bcmol\/min in the control period before CBDL (P &amp;lt; 0.001). This antinatriuresis was associated with a significant rise in plasma aldosterone concentration, from 52.5 \u00b1 5.5 pg\/ml before CBDL to 177 \u00b1 50 pg\/ml after CBDL (P &amp;lt; 0.02). Ascites was present in all salt-retaining CBDL dogs.<\/jats:p>\n               <jats:p>3. Bilateral adrenalectomy resulted in disappearance of ascites and in a rise in the natriuretic response to extracellular volume expansion. Urinary sodium excretion was 770 \u00b1 124 \u03bcmol\/min, a value significantly higher than in the CBDL dogs with intact adrenals (P &amp;lt; 0.001). Sodium balance studies in the adrenalectomized CBDL dogs during chronic deoxycorticosterone acetate (DOCA) treatment (25 mg\/day) showed that in these animals there was failure to escape from the mineralocorticoid-induced sodium retention. Glomerular filtration rate and renal plasma flow did not change during the studies.<\/jats:p>\n               <jats:p>4. The present evidence supports the thesis that sodium retention in the CBDL dog results from a dual mechanism: (a) excess of circulating aldosterone and (b) an extra-adrenal factor which prevents escape from the salt-retaining effect of mineralocorticoids, in the CBDL dogs, thereby perpetuating the antinatriuresis in these animals.<\/jats:p>","DOI":"10.1042\/cs0620065","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:39:49Z","timestamp":1438943989000},"page":"65-70","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pathogenesis of Salt Retention in Dogs with Chronic Bile-Duct Ligation"],"prefix":"10.1042","volume":"62","author":[{"given":"C.","family":"Chaimovitz","sequence":"first","affiliation":[{"name":"Division of Nephrology, Rambam Medical Center, and Technion School of Medicine Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Alon","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Rambam Medical Center, and Technion School of Medicine Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. S.","family":"Better","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Rambam Medical Center, and Technion School of Medicine Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/62\/1\/65\/453308\/cs0620065.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/62\/1\/65\/453308\/cs0620065.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:21:39Z","timestamp":1638476499000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/62\/1\/65\/73011\/Pathogenesis-of-Salt-Retention-in-Dogs-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0620065","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1,1]]}}}