{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:39:54Z","timestamp":1759541994863},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,7,1]]},"abstract":"<jats:p>1. Unexplained cardiorespiratory arrests have been reported in patients with diabetic autonomic neuropathy and these could be due to denervation of the carotid chemoreceptors.<\/jats:p>\n               <jats:p>2. We have studied the ventilatory response to transient hypoxia () during exercise in 22 male diabetic patients, six with symptomatic and cardiovascular evidence to suggest diabetic autonomic neuropathy (DAN+) and 12 without these features (DAN\u2212).<\/jats:p>\n               <jats:p>3. There was no difference in the ventilatory response to transient hypoxia between the different groups of diabetic patients ( in DAN+ patients = \u22120\u00b79 \u00b1 0\u00b72 litre min\u22121 kPa\u22121; in DAN\u2212 patients = \u22121\u00b72 \u00b1 0\u00b76 litres min\u22121 kPa\u22121) even allowing for differences in the level of exercise achieved (CO2 production in DAN+ patients = 743 \u00b1 103 ml\/min; CO2 production in DAN\u2013 patients = 800 \u00b1 144 ml\/min). These results fell within our normal range for ventilatory response to transient hypoxia at this level of exercise.<\/jats:p>\n               <jats:p>4. The heart rate response to transient hypoxia varied within the groups but was significantly (P &amp;lt; 0\u00b705) less in the patients with established diabetic autonomic neuropathy.<\/jats:p>\n               <jats:p>5. We conclude that the peripheral chemoreceptors are intact in diabetic autonomic neuropathy and that other mechanisms must be implicated in the unexpected cardiorespiratory arrests seen in these patients.<\/jats:p>","DOI":"10.1042\/cs0630017","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:41:01Z","timestamp":1438944061000},"page":"17-22","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Preservation of the Hypoxic Drive to Breathing in Diabetic Autonomic Neuropathy"],"prefix":"10.1042","volume":"63","author":[{"given":"P. M. A.","family":"Calverley","sequence":"first","affiliation":[{"name":"1University Department of Medicine, Royal Infirmary, Edinburgh, and Respiratory Medicine, City Hospital, Edinburgh, and Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Ewing","sequence":"additional","affiliation":[{"name":"2University Department of Medicine, Royal Infirmary, Edinburgh, and Respiratory Medicine, City Hospital, Edinburgh, and Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. W.","family":"Campbell","sequence":"additional","affiliation":[{"name":"3University Department of Medicine, Royal Infirmary, Edinburgh, and Respiratory Medicine, City Hospital, Edinburgh, and Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. K.","family":"Wraith","sequence":"additional","affiliation":[{"name":"4University Department of Medicine, Royal Infirmary, Edinburgh, and Respiratory Medicine, City Hospital, Edinburgh, and Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. M.","family":"Brash","sequence":"additional","affiliation":[{"name":"5University Department of Medicine, Royal Infirmary, Edinburgh, and Respiratory Medicine, City Hospital, Edinburgh, and Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. F.","family":"Clarke","sequence":"additional","affiliation":[{"name":"6University Department of Medicine, Royal Infirmary, Edinburgh, and Respiratory Medicine, City Hospital, Edinburgh, and Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Flenley","sequence":"additional","affiliation":[{"name":"7University Department of Medicine, Royal Infirmary, Edinburgh, and Respiratory Medicine, City Hospital, Edinburgh, and Diabetic and Dietetic Department, Royal Infirmary, Edinburgh, Scotland, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/1\/17\/501935\/cs0630017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/1\/17\/501935\/cs0630017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:19:50Z","timestamp":1638476390000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/63\/1\/17\/72916\/Preservation-of-the-Hypoxic-Drive-to-Breathing-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0630017","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7,1]]}}}