{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:30:46Z","timestamp":1760189446270},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,7,1]]},"abstract":"<jats:p>1. The effects of indomethacin on water excretion during both vasopressin stimulation and inhibition were studied in control subjects and in patients with sickle cell anaemia.<\/jats:p>\n               <jats:p>2. In the control group as well as in the group of patients with sickle cell anaemia sodium and urea retention occurred after indomethacin in the water-depleted state. During water loading, indomethacin induced sodium retention without urea reabsorption.<\/jats:p>\n               <jats:p>3. In healthy volunteers indomethacin increased urinary osmolality during water deprivation, but not after water loading. In contrast, in patients with sickle cell anaemia indomethacin caused a rise in urinary osmolality during water loading, but not after water deprivation.<\/jats:p>\n               <jats:p>4. The findings support the view that indomethacin promotes solute reabsorption in the distal tubule.<\/jats:p>\n               <jats:p>5. From our observations we conclude that renal prostaglandins are not involved in the urinary concentrating defect of patients with sickle cell anaemia. On the other hand, the normal diluting capacity in sickle cell anaemia appears to depend on renal prostaglandins.<\/jats:p>","DOI":"10.1042\/cs0630053","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:41:01Z","timestamp":1438944061000},"page":"53-58","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The Influence of Indomethacin on Renal Concentrating and Diluting Capacity in Sickle Cell Nephropathy"],"prefix":"10.1042","volume":"63","author":[{"given":"P. E.","family":"de Jong","sequence":"first","affiliation":[{"name":"1Departments of Medicine and Clinical Chemistry, St Elisabeth Hospital, Willemstad, Cura\u00e7ao, Netherlands Antilles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. T. W.","family":"de Jong-Van Den Berg","sequence":"additional","affiliation":[{"name":"2Departments of Medicine and Clinical Chemistry, St Elisabeth Hospital, Willemstad, Cura\u00e7ao, Netherlands Antilles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"de Zeeuw","sequence":"additional","affiliation":[{"name":"3Departments of Medicine and Clinical Chemistry, St Elisabeth Hospital, Willemstad, Cura\u00e7ao, Netherlands Antilles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J. M.","family":"Donker","sequence":"additional","affiliation":[{"name":"4Departments of Medicine and Clinical Chemistry, St Elisabeth Hospital, Willemstad, Cura\u00e7ao, Netherlands Antilles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Schouten","sequence":"additional","affiliation":[{"name":"5Departments of Medicine and Clinical Chemistry, St Elisabeth Hospital, Willemstad, Cura\u00e7ao, Netherlands Antilles"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. W. Statius","family":"van Eps","sequence":"additional","affiliation":[{"name":"6Departments of Medicine and Clinical Chemistry, St Elisabeth Hospital, Willemstad, Cura\u00e7ao, Netherlands Antilles"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/1\/53\/501915\/cs0630053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/1\/53\/501915\/cs0630053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:19:46Z","timestamp":1638476386000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/63\/1\/53\/72910\/The-Influence-of-Indomethacin-on-Renal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0630053","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7,1]]}}}