{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T13:57:15Z","timestamp":1697983035259},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,7,1]]},"abstract":"<jats:p>1. To compare the bioavailability and the elimination of propranolol in seven untreated coeliac patients and six normal subjects, plasma concentrations were measured after oral and intravenous propranolol. The bioavailability and clearance of propranolol were similar in both groups.<\/jats:p>\n               <jats:p>2. With the use of a perfusion technique, propranolol absorption in the proximal jejunum was found to be decreased by 71% in five untreated coeliac patients, compared with the absorption in four normal subjects.<\/jats:p>\n               <jats:p>3. These results indicate that propranolol absorption is decreased in the proximal jejunum in untreated coeliac disease but overall absorption in the small bowel is not impaired.<\/jats:p>","DOI":"10.1042\/cs0630081","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:41:01Z","timestamp":1438944061000},"page":"81-85","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Propranolol Absorption in Untreated Coeliac Disease"],"prefix":"10.1042","volume":"63","author":[{"given":"G. I.","family":"Sandle","sequence":"first","affiliation":[{"name":"1Gastroenterology Unit and Department of Clinical Pharmacology, Royal Victoria Infirmary and University of Newcastle upon Tyne, Newcastle upon Tyne, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Ward","sequence":"additional","affiliation":[{"name":"2Gastroenterology Unit and Department of Clinical Pharmacology, Royal Victoria Infirmary and University of Newcastle upon Tyne, Newcastle upon Tyne, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. D.","family":"Rawlins","sequence":"additional","affiliation":[{"name":"3Gastroenterology Unit and Department of Clinical Pharmacology, Royal Victoria Infirmary and University of Newcastle upon Tyne, Newcastle upon Tyne, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. O.","family":"Record","sequence":"additional","affiliation":[{"name":"4Gastroenterology Unit and Department of Clinical Pharmacology, Royal Victoria Infirmary and University of Newcastle upon Tyne, Newcastle upon Tyne, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/1\/81\/501956\/cs0630081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/1\/81\/501956\/cs0630081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:19:55Z","timestamp":1638476395000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/63\/1\/81\/72921\/Propranolol-Absorption-in-Untreated-Coeliac"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0630081","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,7,1]]}}}