{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:01:15Z","timestamp":1791417675593,"version":"4.3.3"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,8,1]]},"abstract":"<jats:p>1. A form of skeletal muscle fatigue was examined with isolated animal and human muscle preparations. The possibility that methylxanthines could overcome this was investigated.<\/jats:p>\n               <jats:p>2. Prolonged contractile activity resulted in a long-lasting impairment of force generation at low frequencies of stimulation at times when the force at higher frequencies had substantially recovered. This was seen with both fast-twitch and slow-twitch animal muscles and with samples of isolated human muscle.<\/jats:p>\n               <jats:p>3. The decrease in low-frequency force was due to a decrease in twitch amplitude, suggesting damage to the processes involved in excitation-contraction coupling.<\/jats:p>\n               <jats:p>4. Caffeine and theophylline at concentrations of 1 mmol\/l rapidly and completely reversed the effects of this form of fatigue in both animal and human muscle preparations.<\/jats:p>\n               <jats:p>5. Agents that potentiate muscle force production could be an effective means of counteracting the effects of an important form of skeletal muscle fatigue, but a clinically useful compound would need to be more potent than the methylxanthines currently in use.<\/jats:p>","DOI":"10.1042\/cs0630161","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:41:01Z","timestamp":1438944061000},"page":"161-167","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Low-Frequency Fatigue in Isolated Skeletal Muscles and the Effects of Methylxanthines"],"prefix":"10.1042","volume":"63","author":[{"given":"D. A.","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Human Metabolism, Faculty of Clinical Sciences, University College London, Rayne Institute, University Street, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Howell","sequence":"additional","affiliation":[{"name":"Meakin-Christie Laboratories, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Roussos","sequence":"additional","affiliation":[{"name":"Meakin-Christie Laboratories, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. H. T.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Human Metabolism, Faculty of Clinical Sciences, University College London, Rayne Institute, University Street, London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/2\/161\/453508\/cs0630161.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/2\/161\/453508\/cs0630161.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:19:55Z","timestamp":1638476395000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/63\/2\/161\/72922\/Low-Frequency-Fatigue-in-Isolated-Skeletal-Muscles"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0630161","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8,1]]}}}