{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:12:56Z","timestamp":1762161176098},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,8,1]]},"abstract":"<jats:p>1. In a cross-sectional study, 32 insulin-treated diabetic patients had elevated low shear (27\u00b71 vs 22\u00b71 mPa s, P &amp;lt; 0\u00b705) and high shear blood viscosity (5\u00b74 vs 5\u00b70 mPa s, P &amp;lt; 0\u00b705) when compared with 10 non-diabetic controls. After correction to 45% packed cell volume, the abnormality had a tendency to be greater in patients with proliferative (mean low shear viscosity, 30\u00b78 mPa s) than background (29\u00b72 mPa s) or nil\/minimal retinopathy (27\u00b76 mPa s, 0\u00b705 &amp;lt; P &amp;lt; 0\u00b707, permutational trend test).<\/jats:p>\n               <jats:p>2. The fibrinogen levels were higher in the diabetic group (P &amp;lt; 0\u00b705) and correlated with the low shear blood viscosity (rs = 0\u00b738, P &amp;lt; 0\u00b705).<\/jats:p>\n               <jats:p>3. In a prospective study, 74 insulin-treated diabetic patients with background retinopathy were randomized into two groups. Thirty-six patients were on attempted improved therapy (A group); in these the mean glycosylated haemoglobin (Hb A1c) fell within 1 year (11\u00b76 to 10\u00b71%, P &amp;lt; 0\u00b7001). Both the corrected low shear blood and plasma viscosity fell similarly (P &amp;lt; 0\u00b7001). The fall was greater than in those patients who were kept on usual therapy (U group) and whose glycosylated haemoglobin did not change significantly (11\u00b77 to 11\u00b74%) over the year.<\/jats:p>\n               <jats:p>4. The effect of diabetes on blood viscosity may not be a direct pathological factor, as the same increased viscosity would be produced by a mean increase of 1\u00b77% in packed cell volume, compared with a population range of 14% packed cell volume.<\/jats:p>","DOI":"10.1042\/cs0630211","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:41:01Z","timestamp":1438944061000},"page":"211-216","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Blood Viscosity, Glycaemic Control and Retinopathy in Insulin-Dependent Diabetes"],"prefix":"10.1042","volume":"63","author":[{"given":"P. Y. W.","family":"Poon","sequence":"first","affiliation":[{"name":"Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. L.","family":"Dornan","sequence":"additional","affiliation":[{"name":"Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Orde-Peckar","sequence":"additional","affiliation":[{"name":"The Nuffield Laboratory of Ophthalmology, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Mullins","sequence":"additional","affiliation":[{"name":"Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. J.","family":"Bron","sequence":"additional","affiliation":[{"name":"The Nuffield Laboratory of Ophthalmology, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Turner","sequence":"additional","affiliation":[{"name":"Diabetes Research Laboratories, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Woodstock Road, Oxford, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/2\/211\/453586\/cs0630211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/2\/211\/453586\/cs0630211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:21:03Z","timestamp":1638476463000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/63\/2\/211\/72971\/Blood-Viscosity-Glycaemic-Control-and-Retinopathy"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1982,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0630211","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,8,1]]}}}