{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:10:12Z","timestamp":1779235812242,"version":"3.51.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1982,12,1]]},"abstract":"<jats:p>1. The antidiuretic effect of hydrochlorothiazide in diabetes insipidus was investigated in rats with the hereditary hypothalamic form of the disease (Brattleboro rats).<\/jats:p>\n               <jats:p>2. Administration of hydrochlorothiazide in the food resulted in a marked fall in urine volume and a corresponding rise in osmolality. These effects persisted throughout the period of treatment (6\u20137 days).<\/jats:p>\n               <jats:p>3. Body weight and extracellular volume were significantly reduced in the thiazide-treated rats.<\/jats:p>\n               <jats:p>4. Hydrochlorothiazide caused an increase in urinary sodium excretion only on the first day of treatment. The resulting small negative sodium balance (in comparison with untreated rats) remained statistically significant for 2 days only. Thiazide-treated rats gradually developed a potassium deficit which was statistically significant from the fourth day of treatment.<\/jats:p>\n               <jats:p>5. Total exchangeable sodium, measured after 7 days of thiazide treatment, was not significantly different from that of untreated rats. However, plasma sodium was reduced in thiazide-treated animals, whereas erythrocyte sodium concentration was elevated.<\/jats:p>\n               <jats:p>6. It is concluded that the antidiuresis resulting from chronic hydrochlorothiazide administration is associated with a reduction in extracellular volume, but not with a significant overall sodium deficit. Hydrochlorothiazide appears to cause a redistribution of the body's sodium such that the amount of sodium in the extracellular fluid compartment is reduced.<\/jats:p>","DOI":"10.1042\/cs0630525","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:41:01Z","timestamp":1438944061000},"page":"525-532","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The Antidiuretic Effect of Chronic Hydrochlorothiazide Treatment in Rats with Diabetes Insipidus: Water and Electrolyte Balance"],"prefix":"10.1042","volume":"63","author":[{"given":"S. J.","family":"Walter","sequence":"first","affiliation":[{"name":"1Department of Physiology, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Skinner","sequence":"additional","affiliation":[{"name":"2Department of Physiology, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. F.","family":"Laycock","sequence":"additional","affiliation":[{"name":"3Department of Physiology, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. G.","family":"Shirley","sequence":"additional","affiliation":[{"name":"4Department of Physiology, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/6\/525\/453631\/cs0630525.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/63\/6\/525\/453631\/cs0630525.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:18:40Z","timestamp":1638476320000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/63\/6\/525\/72800\/The-Antidiuretic-Effect-of-Chronic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1982,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0630525","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,12,1]]}}}