{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:04:53Z","timestamp":1778274293811,"version":"3.51.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,2,1]]},"abstract":"<jats:p>1. The erythrocyte content of sodium and of potassium were measured in 231 unselected patients with hypokalaemia, and together with net ouabain-sensitive sodium efflux in patients with severe hypokalaemia, before (20 patients) and during potassium repletion (14 patients).<\/jats:p>\n               <jats:p>2. The erythrocytes of the patients with hypokalaemia compared with control subjects had on average an increase in sodium content, a decrease in potassium content and a reduction in the rate constant of ouabain-sensitive sodium efflux. All three changes had a similar curvilinear relation to the concentration of potassium in plasma with relatively little change in the measured variable unless the plasma potassium was very low.<\/jats:p>\n               <jats:p>3. There was a similar curvilinear relation between the final sodium and potassium content of normal erythrocytes and the potassium concentration of the medium in which they were incubated for 48 h in vitro.<\/jats:p>\n               <jats:p>4. These results suggest that the changes in the sodium and potassium content of erythrocytes in hypokalaemia are due to a direct inhibiting effect of the hypokalaemia on the activity of the sodium pump.<\/jats:p>\n               <jats:p>5. In many patients with hypokalaemia of moderate degree the increase in erythrocyte sodium content was less than expected from the effect in vitro of a low extracellular potassium concentration. This finding suggests that a compensatory change, presumably an increase in the number of sodium pumps, is a common event even in moderate hypokalaemia.<\/jats:p>","DOI":"10.1042\/cs0640167","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:43:01Z","timestamp":1438944181000},"page":"167-176","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Erythrocyte Sodium and Potassium in Patients with Hypokalaemia"],"prefix":"10.1042","volume":"64","author":[{"given":"M.","family":"Cumberbatch","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, University of Leeds, and St Andrew's Hospital, Billericay, Essex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, University of Leeds, and St Andrew's Hospital, Billericay, Essex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/64\/2\/167\/461210\/cs0640167.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/64\/2\/167\/461210\/cs0640167.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:10:06Z","timestamp":1638479406000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/64\/2\/167\/93089\/Erythrocyte-Sodium-and-Potassium-in-Patients-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0640167","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2,1]]}}}