{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:49:15Z","timestamp":1770486555317,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,2,1]]},"abstract":"<jats:p>1. The sodium content, the ouabain-sensitive sodium efflux and efflux rate constant and the ouabain-binding capacity were measured in the erythrocytes of 53 patients with hypokalaemia and in 37 healthy controls. The sodium content alone was measured in a further 57 patients with hypokalaemia.<\/jats:p>\n               <jats:p>2. In the patients with hypokalaemia there was an increase in the average sodium content of the erythrocytes, which was entirely due to a reduction in the ouabain-sensitive efflux rate constant.<\/jats:p>\n               <jats:p>3. The ratio of the ouabain-sensitive efflux rate constant to the number of sodium pumps was decreased in the patients with hypokalaemia, and was directly related to the plasma potassium.<\/jats:p>\n               <jats:p>4. Many patients with moderate hypokalaemia had normal erythrocyte sodium and potassium contents and normal ouabain-sensitive efflux rate constant. These patients had an increased number of sodium pumps, which compensated for the inhibitory effect of hypokalaemia on each sodium pump.<\/jats:p>\n               <jats:p>5. This increase in the number of sodium pumps was common even in patients who had probably had hypokalaemia for less than 2 weeks. This finding suggests that there are latent sodium pumps within the circulating erythrocytes.<\/jats:p>","DOI":"10.1042\/cs0640177","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:43:01Z","timestamp":1438944181000},"page":"177-182","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Effect of Hypokalaemia on the Ouabain-Sensitive Sodium Transport and the Ouabain-Binding Capacity in Human Erythrocytes"],"prefix":"10.1042","volume":"64","author":[{"given":"E. Jill","family":"Rubython","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, University of Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology, University of Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/64\/2\/177\/461286\/cs0640177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/64\/2\/177\/461286\/cs0640177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:11:08Z","timestamp":1638479468000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/64\/2\/177\/93163\/Effect-of-Hypokalaemia-on-the-Ouabain-Sensitive"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0640177","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,2,1]]}}}