{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:21:14Z","timestamp":1761513674372},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,3,1]]},"abstract":"<jats:p>1. The epidemiological characteristics of plasma renin activity (PRA) were established in 1999 members of occupational groups in North and West London.<\/jats:p>\n               <jats:p>2. The main finding was that PRA was inversely associated with systolic blood pressure in men, the percentage fall in PRA (on a log scale) being 8.4% for each increase of one standard deviation in systolic blood pressure. There was a less obvious inverse relationship in women.<\/jats:p>\n               <jats:p>3. However, blood pressure accounted for less than 1% of the variance in PRA.<\/jats:p>\n               <jats:p>4. Mean PRA in both smokers and ex-smokers was about 20% higher than in non-smokers.<\/jats:p>\n               <jats:p>5. PRA fell with increasing age, was lower in women than in men and considerably lower in blacks (of either sex) than whites.<\/jats:p>\n               <jats:p>6. PRA was lower in the first quarter of the menstrual cycle than in the rest of the cycle.<\/jats:p>\n               <jats:p>7. Haemoglobin, blood cholesterol, leucocyte count and Factor VIII were positively correlated with PRA.<\/jats:p>\n               <jats:p>8. PRA was lower in men with diagnosed hypertension than in those without; there was no significant difference in the women.<\/jats:p>\n               <jats:p>9. PRA was lower in those who had had myocardial infarcts in the past than in those who had not.<\/jats:p>\n               <jats:p>10. The data as a whole suggest that it may be low, not high, levels of PRA which are associated with increased risks of cardiovascular disease in which hypertension is a predisposing factor.<\/jats:p>\n               <jats:p>11. The explanation may be a homoeostatic fall in PRA in response to a rise in blood pressure rather than a major causal role for PRA in the pathogenesis of essential hypertension and target-organ damage.<\/jats:p>","DOI":"10.1042\/cs0640273","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:43:01Z","timestamp":1438944181000},"page":"273-280","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["The Epidemiology of Plasma Renin"],"prefix":"10.1042","volume":"64","author":[{"given":"T. W.","family":"Meade","sequence":"first","affiliation":[{"name":"MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middx., U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Imeson","sequence":"additional","affiliation":[{"name":"MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middx., U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gordon","sequence":"additional","affiliation":[{"name":"Medical Unit, St Mary's Hospital Medical School, London"},{"name":"MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middx., U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. S.","family":"Peart","sequence":"additional","affiliation":[{"name":"Medical Unit, St Mary's Hospital Medical School, London"},{"name":"MRC Epidemiology and Medical Care Unit, Northwick Park Hospital, Harrow, Middx., U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/64\/3\/273\/453915\/cs0640273.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/64\/3\/273\/453915\/cs0640273.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:22:46Z","timestamp":1638476566000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/64\/3\/273\/73073\/The-Epidemiology-of-Plasma-Renin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0640273","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,3,1]]}}}