{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T23:10:05Z","timestamp":1785798605567,"version":"3.56.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,6,1]]},"abstract":"<jats:p>1. Urinary and plasma levels of adenosine 3\u2032:5\u2032-cyclic monophosphate (cyclic AMP) after an intravenous injection of bovine parathyroid hormone (PTH) were measured in 12 patients on long-term lithium treatment and in nine control subjects. The maximum urine osmolality (Umax.) after an intravenous injection of desamino-d-arginine vasopressin (DDAVP) was also measured.<\/jats:p>\n               <jats:p>2. in all the control subjects and six of the patients, the Umax. after DDAVP exceeded 700 mosmol\/kg. The cyclic AMP responses in these two groups did not differ significantly.<\/jats:p>\n               <jats:p>3. in the remaining six patients whose Umax. did not reach 700 mosmol\/kg, the cyclic AMP response to PTH was significantly less than that of the controls.<\/jats:p>\n               <jats:p>4. A strong correlation was demonstrated in the patients between the urinary cyclic AMP response after PTH and the maximum osmolality after the administration of DDAVP.<\/jats:p>\n               <jats:p>5. These observations are consistent with the hypothesis that reduced adenylate cyclase activity contributes to the development of nephrogenic diabetes insipidus in patients on long-term lithium treatment.<\/jats:p>","DOI":"10.1042\/cs0640623","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:43:01Z","timestamp":1438944181000},"page":"623-627","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Impairment of Cyclic AMP Response to Bovine Parathyroid Hormone in Patients on Chronic Lithium Therapy with Diminished Renal Urine-Concentrating Ability"],"prefix":"10.1042","volume":"64","author":[{"given":"D. G.","family":"Waller","sequence":"first","affiliation":[{"name":"University of Southampton Department of Renal and Endocrine Medicine, St Mary's Hospital, Portsmouth, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D. M.","family":"Albano","sequence":"additional","affiliation":[{"name":"University of Southampton Department of Renal and Endocrine Medicine, St Mary's Hospital, Portsmouth, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. G. B.","family":"Millar","sequence":"additional","affiliation":[{"name":"University of Southampton Department of Renal and Endocrine Medicine, St Mary's Hospital, Portsmouth, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Polak","sequence":"additional","affiliation":[{"name":"University of Southampton Department of Renal and Endocrine Medicine, St Mary's Hospital, Portsmouth, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/64\/6\/623\/454147\/cs0640623.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/64\/6\/623\/454147\/cs0640623.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:18:27Z","timestamp":1638476307000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/64\/6\/623\/72774\/Impairment-of-Cyclic-AMP-Response-to-Bovine"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1983,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0640623","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,6,1]]}}}