{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,12]],"date-time":"2024-05-12T20:56:25Z","timestamp":1715547385871},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,7,1]]},"abstract":"<jats:p>1. Blood pressure, plasma and aortic renin concentrations were measured in Goldblatt two-kidney one-clip hypertensive rats before and after surgical correction by removing the renal artery clip.<\/jats:p>\n               <jats:p>2. Blood pressure fell rapidly in the first hour and then more slowly over 24 h.<\/jats:p>\n               <jats:p>3. Plasma renin concentration fell into the normal range by 3 h after unclipping.<\/jats:p>\n               <jats:p>4. Aortic renin concentration was markedly raised in hypertensive rats and declined slowly after unclipping, being virtually unchanged at 3 h and reaching normal levels at 24 h.<\/jats:p>\n               <jats:p>5. The fall in blood pressure produced by removal of the renal artery clip in Goldblatt two-kidney one-clip hypertensive rats does not depend upon the renin-angiotensin system in plasma and vascular tissue and indicates that a renal vasodepressor system may be involved.<\/jats:p>","DOI":"10.1042\/cs0650033","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:46:18Z","timestamp":1438944378000},"page":"33-36","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Surgical Reversal of Renovascular Hypertension in Rats: Changes in Blood Pressure, Plasma and Aortic Renin"],"prefix":"10.1042","volume":"65","author":[{"given":"Joan M.","family":"Brice","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. I.","family":"Russell","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. F.","family":"Bing","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D.","family":"Swales","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Thurston","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Leicester, Leicester Royal Infirmary, Leicester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/1\/33\/454187\/cs0650033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/1\/33\/454187\/cs0650033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:22:10Z","timestamp":1638476530000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/65\/1\/33\/73047\/Surgical-Reversal-of-Renovascular-Hypertension-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0650033","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,7,1]]}}}