{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:29:36Z","timestamp":1698125376951},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,8,1]]},"abstract":"<jats:p>1. \u03b3-Glutamyl l-dopa, a renal pro-drug for dopamine, was administered to rats before and after injection of glycerol, and to a control group which received water in place of glycerol. A third group of rats was given glycerol but no \u03b3-glutamyl l-dopa.<\/jats:p>\n               <jats:p>2. The plasma creatinine in rats given \u03b3-glutamyl l-dopa and glycerol was significantly lower than in rats receiving glycerol alone.<\/jats:p>\n               <jats:p>3. The fall in urine creatinine excretion, and polyuria, after glycerol was reduced by \u03b3-glutamyl l-dopa and the natriuresis abolished.<\/jats:p>\n               <jats:p>4. \u03b3-Glutamyl l-dopa given alone caused a 4000-fold increase in urine dopamine excretion, associated with a natriuresis.<\/jats:p>\n               <jats:p>5. The administration of \u03b3-glutamyl l-dopa reduces the severity of renal failure produced by glycerol.<\/jats:p>","DOI":"10.1042\/cs0650159","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:46:18Z","timestamp":1438944378000},"page":"159-164","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Protective Effect of \u03b3-Glutamyl <scp>l<\/scp>-Dopa on the Glycerol Treated Rat Model of Acute Renal Failure"],"prefix":"10.1042","volume":"65","author":[{"given":"I. F.","family":"Casson","sequence":"first","affiliation":[{"name":"Departments of Medicine and Community Medicine, The University of Leeds, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Clayden","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Community Medicine, The University of Leeds, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. F.","family":"Cope","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Community Medicine, The University of Leeds, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. R.","family":"Lee","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Community Medicine, The University of Leeds, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/2\/159\/454257\/cs0650159.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/2\/159\/454257\/cs0650159.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:25:24Z","timestamp":1638476724000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/65\/2\/159\/73181\/The-Protective-Effect-of-Glutamyl-l-Dopa-on-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0650159","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,8,1]]}}}