{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:44:29Z","timestamp":1773755069273,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,9,1]]},"abstract":"<jats:p>1. In spontaneously breathing dogs (n = 8), maintained in the upright position, bronchial luminal diameter was measured from tantalum bronchograms. Changes in total intrathoracic lung volume were measured from radiographs taken at functional residual capacity (FRCR).<\/jats:p>\n               <jats:p>2. With cooling of the cervical vagi to 0\u20134\u00b0C mean bronchial diameter increased to 117 \u00b115 (sd)% of baseline diameter and FRCR increased to 113 \u00b1 16 of baseline volumes respectively. There was a significant correlation between changes in FRCR and bronchial diameter.<\/jats:p>\n               <jats:p>3. After the vagi were rewarmed, pulmonary oedema was induced by rapid intravenous infusion of Hartmann's solution. Bronchi narrowed to a mean of 86 \u00b1 9% of baseline calibre and FRCR decreased (mean = 95 \u00b1 15%).<\/jats:p>\n               <jats:p>4. With vagotomy bronchial diameter increased (mean = 102 \u00b1 12% of baseline diameter) but FRCR did not change significantly.<\/jats:p>\n               <jats:p>5. Excluding one dog with gross oedema, changes in bronchial diameter due to oedema correlated positively with changes in FRCR; after vagotomy the relationship between diameter and FRCR was similar to that seen after vagal cooling in the baseline state, though individual values were lower.<\/jats:p>\n               <jats:p>6. The shift in the diameter-FRCR relationship with vagotomy demonstrates that the direct bronchoconstrictor effect of the vagus is approximately doubled in the presence of pulmonary oedema.<\/jats:p>\n               <jats:p>7. Bronchial and peribronchial oedema does not appear to directly narrow the bronchial lumen.<\/jats:p>","DOI":"10.1042\/cs0650289","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:46:18Z","timestamp":1438944378000},"page":"289-296","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Mechanisms of Airway Narrowing in Acute Pulmonary Oedema in Dogs: Influence of the Vagus and Lung Volume"],"prefix":"10.1042","volume":"65","author":[{"given":"K. F.","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Medicine, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. J.","family":"Keyes","sequence":"additional","affiliation":[{"name":"Department of Medicine, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. M.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. W.","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Medicine, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. D.","family":"Snashall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Charing Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/3\/289\/456900\/cs0650289.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/3\/289\/456900\/cs0650289.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:06:59Z","timestamp":1638479219000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/65\/3\/289\/92621\/Mechanisms-of-Airway-Narrowing-in-Acute-Pulmonary"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0650289","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,9,1]]}}}