{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:59:33Z","timestamp":1757541573974},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,10,1]]},"abstract":"<jats:p>1. \u03b4-Aminolaevulinate dehydratase activity was measured in liver biopsy specimens from 13 patients with porphyria cutanea tarda, 13 alcoholics and 10 control subjects.<\/jats:p>\n               <jats:p>2. The mean enzyme activities in liver of porphyria cutanea tarda and alcoholics were 34% (P &amp;lt; 0.001) and 49% (P &amp;lt; 0.001) respectively of the control level.<\/jats:p>\n               <jats:p>3. Heat treatment of liver supernatant caused slight inhibition of the enzyme activity in porphyria cutanea tarda and in controls.<\/jats:p>\n               <jats:p>4. Addition of Zn2+ to liver supernatants slightly increased the enzyme activity in both porphyria cutanea tarda and controls.<\/jats:p>\n               <jats:p>5. The addition of liver supernatant from the porphyria cutanea tarda to purified bovine 6\u2013aminolaevulinate dehydratase did not result in suppression of the enzyme activity.<\/jats:p>\n               <jats:p>6. The apparent Km value of \u03b4-aminolaevulinate dehydratase was 4.3 \u00d7 10\u20134 mol\/l for porphyria cutanea tarda livers and 3.3 \u00d7 10\u20134 mol\/l for control livers. The difference between the two was not significant.<\/jats:p>","DOI":"10.1042\/cs0650423","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:46:18Z","timestamp":1438944378000},"page":"423-428","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Decreased Liver \u03b4-Aminolaevulinate Dehydratase Activity in Porphyria Cutanea Tarda and in Alcoholism"],"prefix":"10.1042","volume":"65","author":[{"given":"Masao","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Nutrition and Biochemistry, The Institute of Public Health, Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gumpei","family":"Urata","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Biochemistry, The Institute of Public Health, Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/4\/423\/451003\/cs0650423.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/65\/4\/423\/451003\/cs0650423.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:29:26Z","timestamp":1638476966000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/65\/4\/423\/73343\/Decreased-Liver-Aminolaevulinate-Dehydratase"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1983,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0650423","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10,1]]}}}