{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T17:52:43Z","timestamp":1698169963872},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,4,1]]},"abstract":"<jats:p>1. Sera from patients with fulminant hepatic failure (FHF) has previously been shown to contain substance(s) which inhibit leucocyte ouabain-sensitive sodium efflux and rat brain Na+,K+-dependent ATPase in vitro. Similar effects in the patients could be an important mechanism in the development of encephalopathy and cerebral oedema.<\/jats:p>\n               <jats:p>2. In previous studies, bilirubin, free fatty acids and mercaptans have been shown to inhibit Na+,K+-ATPase in vitro. The present report is concerned with the effects of a number of other potentially toxic substances present in the serum of patients with FHF.<\/jats:p>\n               <jats:p>3. Chenodeoxycholic acid, p-hydroxyphenyllactic acid, p-hydroxyphenylpyruvic acid and endotoxin caused 30\u201345% inhibition of partially purified rat brain Na+,K+-ATPase at concentrations known to occur in the serum of patients with FHF. At low concentrations the inhibitory effects of these substances were additive, but at higher concentrations a maximum level of inhibition was reached.<\/jats:p>\n               <jats:p>4. These further substances are likely, therefore, to be of importance in the disturbances of brain function found in FHF.<\/jats:p>","DOI":"10.1042\/cs0660415","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:50:35Z","timestamp":1438944635000},"page":"415-420","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inhibition of Partially Purified Rat Brain Na+, K+- Dependent Atpase by Bile Acids, Phenolic Acids and Endotoxin"],"prefix":"10.1042","volume":"66","author":[{"given":"H. W. M.","family":"Seda","sequence":"first","affiliation":[{"name":"Liver Unit, King's College Hospital and School of Medicine and Dentistry, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. D.","family":"Gove","sequence":"additional","affiliation":[{"name":"Liver Unit, King's College Hospital and School of Medicine and Dentistry, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. D.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Liver Unit, King's College Hospital and School of Medicine and Dentistry, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Williams","sequence":"additional","affiliation":[{"name":"Liver Unit, King's College Hospital and School of Medicine and Dentistry, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/66\/4\/415\/455214\/cs0660415.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/66\/4\/415\/455214\/cs0660415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:31:57Z","timestamp":1638477117000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/66\/4\/415\/73438\/Inhibition-of-Partially-Purified-Rat-Brain-Na-K"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0660415","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4,1]]}}}