{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T09:06:23Z","timestamp":1721379983168},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,4,1]]},"abstract":"<jats:p>1. To test the hypothesis that the presence of food in the intestine plays a role in the control of serum bilirubin levels, the effect of a 1674 kJ (400 kcal) diet, including non-absorbable material able to produce an intestinal bulk, was compared with the effect of caloric restriction alone.<\/jats:p>\n               <jats:p>2. In normal individuals (n = 10) the rise of plasma bilirubin was comparable after the two trials. In patients with Gilbert's syndrome (n = 18), bilirubin concentration rose to a much greater extent during the caloric restriction as compared with controls, and to a lesser extent (P&amp;lt;0.001) after the bulky diet, as compared with caloric restriction alone in the same patient.<\/jats:p>\n               <jats:p>3. It is proposed that a factor originating from the intestine, perhaps a hormone, the release of which is dependent on the presence of food-bulk, plays a role in the control of hyperbilirubinaemia associated with caloric restriction.<\/jats:p>","DOI":"10.1042\/cs0660493","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:50:35Z","timestamp":1438944635000},"page":"493-496","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of An Intraluminal Food-Bulk on Low Calorie Induced Hyperbilirubinaemia"],"prefix":"10.1042","volume":"66","author":[{"given":"Giovanni L.","family":"Ricci","sequence":"first","affiliation":[{"name":"The Gastroenterology Unit, Medical Clinic 2, University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo R.","family":"Ricci","sequence":"additional","affiliation":[{"name":"The Gastroenterology Unit, Medical Clinic 2, University of Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/66\/4\/493\/455256\/cs0660493.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/66\/4\/493\/455256\/cs0660493.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:34:53Z","timestamp":1638477293000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/66\/4\/493\/73488\/Effect-of-An-Intraluminal-Food-Bulk-on-Low-Calorie"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,4,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,4,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0660493","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,4,1]]}}}