{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:30:47Z","timestamp":1760189447187},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,6,1]]},"abstract":"<jats:p>1. The bronchial response of 11 normal and ten stable asthmatic subjects to increasing concentrations of methacholine aerosol was assessed by serial measurements of specific airways conductance (scaw) in a body plethysmograph.<\/jats:p>\n               <jats:p>2. Cumulative log dose-response curves were constructed. The threshold provocative dose of methacholine needed to cause a 35% fall in starting sCaw (pD35) and the steepest slope of the response were measured from each curve.<\/jats:p>\n               <jats:p>3. On separate days subjects were premedicated with 0.9% NaCl solution (control) in duplicate, chlorpheniramine, salbutamol and atropine, the last-named at two different doses, one twice the other.<\/jats:p>\n               <jats:p>4. Asthmatic subjects had a lower mean PD35 and a lower mean slope than normal subjects.<\/jats:p>\n               <jats:p>5. Pretreatment with salbutamol resulted in a greater increase in sGaw than after atropine but caused a smaller increase in PD35 in both groups. There was a dose-dependent increase in PD3s after the two doses of atropine, but no significant difference in bronchodilatation between doses. Mean steepest slope approximately doubled in these three sets of challenges.<\/jats:p>\n               <jats:p>6. Chlorpheniramine caused a small degree of bronchodilatation and there was a non-significant increase in mean PD3s and in mean steepest slope in both normal and asthmatic groups.<\/jats:p>\n               <jats:p>7. There was a positive linear correlation between starting sGaw and steepest slope in each group of premedicated challenges, such that when<\/jats:p>","DOI":"10.1042\/cs0660665","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:50:35Z","timestamp":1438944635000},"page":"665-673","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Methacholine dose-response curves in normal and asthmatic man: Effect of starting conductance and pharmacological antagonism"],"prefix":"10.1042","volume":"66","author":[{"given":"K. F.","family":"Chung","sequence":"first","affiliation":[{"name":"1Department of Medicine, Grating Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. D.","family":"Snashall","sequence":"additional","affiliation":[{"name":"2Department of Medicine, Grating Cross Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/66\/6\/665\/513388\/cs0660665.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/66\/6\/665\/513388\/cs0660665.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T21:18:03Z","timestamp":1638479883000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/66\/6\/665\/98284\/Methacholine-dose-response-curves-in-normal-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1984,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0660665","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,6,1]]}}}