{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T18:00:37Z","timestamp":1774461637827,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,7,1]]},"abstract":"<jats:p>1. The possible contribution of changes in cardiac \u03b2-adrenoceptors to alterations in cardiac responses to isoprenaline were investigated in hearts isolated from rats with renovascular hypertension (two-kidney, one-clip Goldblatt), 6, 12 and 18 weeks after renal artery clipping. Cardiac responses were determined in vitro (Langendorff preparation), and ventricular \u03b2-adrenoceptors ([3H)dihydroalprenolol, [3H]DHA) were then assayed in the same 44 hearts.<\/jats:p>\n               <jats:p>2. There was no difference between renovascular hypertensive rats (RHR) and matched normotensive controls as regards chronotropic responses to isoprenaline or in atrial \u03b2-adrenoceptor numbers or apparent affinity.<\/jats:p>\n               <jats:p>3. Inotropic responses were significantly lower in all stages of RHR than in matched normotensive controls.<\/jats:p>\n               <jats:p>4. There was also a significant (P &amp;lt; 0.001) decrease in ventricular \u03b2-adrenoceptor density with no significant change in apparent affinity (Kd). Inotropic responsiveness to isoprenaline (max. increment in peak dP\/dt) was significantly correlated with ventricular \u03b2-adrenoceptor density (r = 0.54, P = 0.0005).<\/jats:p>\n               <jats:p>5. These results suggest that the reduction of ventricular \u03b2-adrenoceptor density in that model of hypertension was responsible, at least partially, for the lowered inotropic responsiveness of the same hearts to isoprenaline.<\/jats:p>","DOI":"10.1042\/cs0670051","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:51:28Z","timestamp":1438944688000},"page":"51-59","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["\u03b2-Adrenoceptors and Responsiveness in Cardiac Hypertrophy Associated with Renal Hypertension in Renovascular Hypertensive Rats"],"prefix":"10.1042","volume":"67","author":[{"given":"M. Hani","family":"Ayobe","sequence":"first","affiliation":[{"name":"Research Division, Cleveland Clinic Foundation, Cleveland, OH, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Tarazi","sequence":"additional","affiliation":[{"name":"Research Division, Cleveland Clinic Foundation, Cleveland, OH, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/67\/1\/51\/455266\/cs0670051.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/67\/1\/51\/455266\/cs0670051.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:36:57Z","timestamp":1638477417000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/67\/1\/51\/73545\/Adrenoceptors-and-Responsiveness-in-Cardiac"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0670051","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7,1]]}}}