{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:19:37Z","timestamp":1761059977005},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,7,1]]},"abstract":"<jats:p>1. In order to define the alteration of the function of the adrenergic system in hypertension, we studied directly the receptor-cyclase coupling protein (N protein), which is one of the components of the enzyme adenylate cyclase.<\/jats:p>\n               <jats:p>2. N protein was determined in erythrocyte membranes of patients with essential hypertension and normal subjects, with a complementation assay in vitro. Fifteen normal subjects and 18 patients with essential hypertension (eight untreated and ten treated with \u03b2-adrenoreceptor blocking drugs alone or in combination with other antihypertensive drugs), and two patients with pseudohypoparathyroidism type Ia (known to have deficient N protein activity), were studied.<\/jats:p>\n               <jats:p>3. Erythrocyte N protein activities in the various groups expressed as percentages of the means \u00b1 sd of normals were: normal subjects 100 \u00b1 13.7, untreated hypertensive 108.9 \u00b1 20.4, treated hypertensive 104.3 \u00b1 11.3 and pseudohypoparathyroidism type Ia 43%.<\/jats:p>\n               <jats:p>4. The difference between N protein activity in the hypertensive patients and normals was not statistically significant. We suggest that the molecular basis for the altered sympathetic responsiveness in essential hypertension may reside in other components of the cyclic AMP protein kinase effector system.<\/jats:p>","DOI":"10.1042\/cs0670111","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:51:28Z","timestamp":1438944688000},"page":"111-115","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Receptor-Cyclase Coupling Protein in Erythrocytes of Patients with Essential Hypertension"],"prefix":"10.1042","volume":"67","author":[{"given":"Zvi","family":"Farfel","sequence":"first","affiliation":[{"name":"Clinical Pharmacology Unit, Tel-Hashomer, Tel-Aviv University Medical School, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Iaina","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chaim Sheba Medical Center, Tel-Hashomer, Tel-Aviv University Medical School, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haskel","family":"Eliahou","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Chaim Sheba Medical Center, Tel-Hashomer, Tel-Aviv University Medical School, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohara","family":"Cohen","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit, Tel-Hashomer, Tel-Aviv University Medical School, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/67\/1\/111\/455270\/cs0670111.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/67\/1\/111\/455270\/cs0670111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:37:10Z","timestamp":1638477430000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/67\/1\/111\/73554\/Receptor-Cyclase-Coupling-Protein-in-Erythrocytes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0670111","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,7,1]]}}}