{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T16:08:57Z","timestamp":1761581337077},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,8,1]]},"abstract":"<jats:p>1. Ventral noradrenergic projections (VNAB) from lateral tegmental (A1, A2) and dorsal noradrenergic projections (DNAB) from the coeruleal (A6) as well as A1 cell groups in the brain-stem of the rat were lesioned by intracerebral injection of 6-hydroxydopamine.<\/jats:p>\n               <jats:p>2. A marked increase in plasma renin activity and adrenaline concentrations followed haemorrhage (0.5 ml\/100 g body weight) in the sham-operated rats. VNAB-lesioned rats showed a similar response to the sham-operated controls, but in DNAB-lesioned animals the rise of plasma renin was markedly attenuated.<\/jats:p>","DOI":"10.1042\/cs0670269","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:51:28Z","timestamp":1438944688000},"page":"269-272","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Ascending Brain-Stem Noradrenergic Pathways Modulate the Renin Response to Haemorrhage"],"prefix":"10.1042","volume":"67","author":[{"given":"S. L.","family":"Lightman","sequence":"first","affiliation":[{"name":"Department of Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Todd","sequence":"additional","affiliation":[{"name":"Department of Medicine, Charing Cross and Westminster Medical School, Westminster Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J.","family":"Everitt","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Cambridge, Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Causon","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Royal Postgraduate Medical School, Hammersmith Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/67\/2\/269\/455680\/cs0670269.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/67\/2\/269\/455680\/cs0670269.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:36:53Z","timestamp":1638477413000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/67\/2\/269\/73540\/Ascending-Brain-Stem-Noradrenergic-Pathways"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0670269","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,8,1]]}}}