{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:46:46Z","timestamp":1771645606352,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,12,1]]},"abstract":"<jats:p>1. The effect of acetylsalicylic acid (ASA, 3 g\/day for 3 days) and of indomethacin (IND, 150 mg\/day for 3 days) on diuresis and on the excretion of prostaglandin E2 (PGE2) was studied in six healthy, male volunteers. After overnight deprivation the subjects received an oral water load (20 ml\/kg) and hourly urine volumes were replaced by an equivalent volume of water by mouth for 4 h.<\/jats:p>\n               <jats:p>2. Pretreatment with both ASA and IND induced a comparable suppression (P&amp;lt;0.05 to &amp;lt;0.001) in the excretion of PGE2, but only IND also reduced (P&amp;lt;0.05) diuresis, free water clearance and the excretion of sodium. The excretion of creatinine was uninfluenced by both ASA and IND.<\/jats:p>\n               <jats:p>3. These data indicate that a mechanism other than cyclo-oxygenase inhibition is involved in the effect of IND and ASA on diuresis in man.<\/jats:p>","DOI":"10.1042\/cs0670579","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:51:28Z","timestamp":1438944688000},"page":"579-583","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Acetylsalicylic Acid and of Indomethacin on Diuresis in Man: The Role of Cyclo-Oxygenase Inhibition"],"prefix":"10.1042","volume":"67","author":[{"given":"H.","family":"Vierhapper","sequence":"first","affiliation":[{"name":"Division of Clinical Endocrinology and Diabetes mellitus, I. Medizinische Universit\u00e4tsklinik, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"J\u00f6rg","sequence":"additional","affiliation":[{"name":"Division of Clinical Endocrinology and Diabetes mellitus, I. Medizinische Universit\u00e4tsklinik, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Waldh\u00e4usl","sequence":"additional","affiliation":[{"name":"Division of Clinical Endocrinology and Diabetes mellitus, I. Medizinische Universit\u00e4tsklinik, Wien, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/67\/6\/579\/455883\/cs0670579.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/67\/6\/579\/455883\/cs0670579.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:27:54Z","timestamp":1638476874000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/67\/6\/579\/73246\/Effect-of-Acetylsalicylic-Acid-and-of-Indomethacin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1984,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0670579","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,12,1]]}}}