{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T10:17:47Z","timestamp":1697969867475},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,2,1]]},"abstract":"<jats:p>1. There is evidence that opioid peptides influence blood pressure and heart rate in animals and man. In the present investigation the effect of naloxone on the exercise-induced increase in blood pressure, heart rate, plasma catecholamines, plasma renin activity (PRA) and plasma aldosterone was investigated in nine healthy men. A submaximal work test was performed on two occasions. The test consisted of ergometer bicycling for 10 min on 50% of maximal working capacity immediately followed by 10 min on 80% of maximal working capacity. Ten minutes before exercise the subjects received in a randomized manner a bolus dose of naloxone (10 \u03bcg\/kg) or a corresponding volume of saline followed by a slow infusion (15 ml\/h) of naloxone (5 \u03bc h\u22121 kg\u22121) or saline, respectively.<\/jats:p>\n               <jats:p>2. After exercise systolic blood pressure, heart rate, plasma catecholamines, PRA and plasma aldosterone increased during both saline and naloxone infusion. The changes were similar in both studies.<\/jats:p>\n               <jats:p>3. Accordingly, opiate receptors sensitive to naloxone in a moderate dosage seem not to be involved in the cardiovascular response and the increase in plasma catecholamines, PRA and plasma aldosterone induced by exercise.<\/jats:p>","DOI":"10.1042\/cs0680185","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:57:35Z","timestamp":1438945055000},"page":"185-191","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lack of effect of Naloxone in a Moderate dosage on the Exercise-Induced Increase in Blood Pressure, Heart Rate, Plasma Catecholamines, Plasma Renin Activity and Plasma Aldosterone in Healthy Males"],"prefix":"10.1042","volume":"68","author":[{"given":"Margareta","family":"Bramnert","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Lund University Clinics, Malm\u00f6 General Hospital, Malm\u00f6, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00f6kfelt","family":"Bernt","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Lund University Clinics, Malm\u00f6 General Hospital, Malm\u00f6, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/68\/2\/185\/451089\/cs0680185.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/68\/2\/185\/451089\/cs0680185.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:38:31Z","timestamp":1638477511000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/68\/2\/185\/73637\/Lack-of-effect-of-Naloxone-in-a-Moderate-dosage-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0680185","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,2,1]]}}}