{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T15:02:30Z","timestamp":1745766150809},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,2,1]]},"abstract":"<jats:p>1. Ten healthy subjects received, on separate occasions, intravenous infusions of 0.9% NaCl solution (saline) and of sodium cromoglycate given in a double-blind cross-over fashion.<\/jats:p>\n               <jats:p>2. After 20 min of infusion the specific airway conductance (sGaw) of each subject was measured in a body plethysmograph. The subject then breathed first a low (1-20 p.p.m.) and then a higher (4-40 p.p.m.) concentration of sulphur dioxide (SO2) for 2 min while the infusion continued. Measurements of sGaw were repeated after each inhalation of SO2.<\/jats:p>\n               <jats:p>3. Sodium cromoglycate infusion did not affect the sGaw measured before challenge with SO2.<\/jats:p>\n               <jats:p>4. During the infusion of sodium cromoglycate, the falls in sGaw in response to both concentrations of SO2 were significantly less than those which occurred during saline infusion.<\/jats:p>\n               <jats:p>5. Plasma concentrations of sodium cromoglycate were found to be 209 \u00b1 22 nmol\/l at the end of the drug infusion. This is about one-hundredth of lowest dose required to stabilize mast cells in vitro.<\/jats:p>\n               <jats:p>6. We conclude that sodium cromoglycate acted by a mechanism which did not involve mast cells. Other possible modes of action are discussed.<\/jats:p>","DOI":"10.1042\/cs0680227","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:57:35Z","timestamp":1438945055000},"page":"227-232","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The effect of Intravenous Sodium Cromoglycate on the Bronchoconstriction Induced by Sulphur Dioxide Inhalation in Man"],"prefix":"10.1042","volume":"68","author":[{"given":"Anne","family":"Allistone","sequence":"first","affiliation":[{"name":"Departments of Physiology Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Collier","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pharmacology Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. N.","family":"Davidson","sequence":"additional","affiliation":[{"name":"Departments of Medicine, St George's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. W.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pharmacology Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Departments of Physiology Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/68\/2\/227\/451045\/cs0680227.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/68\/2\/227\/451045\/cs0680227.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:38:13Z","timestamp":1638477493000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/68\/2\/227\/73622\/The-effect-of-Intravenous-Sodium-Cromoglycate-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1985,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0680227","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,2,1]]}}}