{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:22:43Z","timestamp":1761744163241},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,5,1]]},"abstract":"<jats:p>1. Hypokalaemia may be produced in man by intravenous adrenaline infusion, or as a result of pathological disturbances which have led to a high plasma adrenaline concentration.<\/jats:p>\n               <jats:p>2. With isolated human leucocytes used as a cellular model, adrenaline at concentrations at and above 9 nmol\/l increases the influx of rubidium (a model for potassium flux) into cells, with a simultaneous efflux of sodium. There is no effect on Na+, K+-ATPase activity in lysed leucocytes.<\/jats:p>\n               <jats:p>3. Use of the adrenoceptor blockers timolol and atenolol shows that the demonstrated effect of adrenaline on coupled active transport of ions is mediated by \u03b22-adrenoceptors.<\/jats:p>","DOI":"10.1042\/cs0680517","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:57:35Z","timestamp":1438945055000},"page":"517-521","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Adrenaline and ion flux in isolated human leucocytes"],"prefix":"10.1042","volume":"68","author":[{"given":"D. N.","family":"Baron","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachel J.","family":"Green","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. A.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/68\/5\/517\/451320\/cs0680517.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/68\/5\/517\/451320\/cs0680517.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:38:34Z","timestamp":1638477514000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/68\/5\/517\/73639\/Adrenaline-and-ion-flux-in-isolated-human"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0680517","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,5,1]]}}}