{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T18:29:31Z","timestamp":1701196171039},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,6,1]]},"abstract":"<jats:p>1. Muscle protein breakdown in vivo has been studied by measurements of urinary 3-methylhistidine\/creatinine ratios. No differences were found between control subjects and chronic alcoholics either with or without proximal muscle wasting or cirrhosis.<\/jats:p>\n               <jats:p>2. Calculation of muscle turnover rates, with the correction of Afting et al. (1981, Biochemical Journal, 200, 449-452) for non-skeletal muscle contributions of 3-methylhistidine and creatinine, showed lower values for alcoholics compared with controls.<\/jats:p>\n               <jats:p>3. Tissue activities of a neutral protease, assayed by a novel, rapid and sensitive fluorimetric method, were similar in patients and controls. The activity did not vary with severity of atrophy or the presence of cirrhosis.<\/jats:p>\n               <jats:p>4. No evidence was therefore obtained to suggest that alcoholic myopathy is due to increased muscle breakdown.<\/jats:p>","DOI":"10.1042\/cs0680693","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:57:35Z","timestamp":1438945055000},"page":"693-700","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Assessment <i>in vitro<\/i> and <i>in vivo<\/i> of muscle degradation in chronic skeletal muscle myopathy of alcoholism"],"prefix":"10.1042","volume":"68","author":[{"given":"Finbarr C.","family":"Martin","sequence":"first","affiliation":[{"name":"Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy J.","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Clinical Cell Biology, MRC Clinical Research Centre, Harrow, Middlesex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/68\/6\/693\/456022\/cs0680693.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/68\/6\/693\/456022\/cs0680693.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:23:43Z","timestamp":1638476623000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/68\/6\/693\/73131\/Assessment-in-vitro-and-in-vivo-of-muscle"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,6,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985,6,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0680693","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,6,1]]}}}