{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:12:48Z","timestamp":1791313968821,"version":"4.3.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,9,1]]},"abstract":"<jats:p>1. Two groups of eight normal subjects were investigated in separate studies to demonstrate the effects of changes in end-tidal Pco2, and of pretreatment with the calcium antagonist drug verapamil, on bronchoconstriction provoked by voluntary hyperventilation.<\/jats:p>\n               <jats:p>2. Total respiratory resistance (Ros) was measured by the forced oscillation technique before and after 90s voluntary hyperventilation. End-tidal Pco2 during hyperventilation was varied by altering inspired CO2 concentration. When end-tidal Pco2 fell during hyperventilation, there was a rise in Ros. This did not occur if end-tidal Pco2 was controlled at a normal resting level during hyperventilation.<\/jats:p>\n               <jats:p>3. Specific conductance (sGaw) was measured before and after 90 s voluntary hyperventilation of air. Subjects were treated with oral verapamil or placebo for 2 1\/2 days and the effect of hyperventilation on sGaw was reassessed. Verapamil reduced significantly the fall in sGaw caused by hyperventilation. Placebo had no effect.<\/jats:p>\n               <jats:p>4. In normal humans, bronchoconstriction provoked by hyperventilating air at ambient temperature and humidity is mediated by the fall in Pco2, and is also reduced by verapamil.<\/jats:p>","DOI":"10.1042\/cs0690361","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:59:20Z","timestamp":1438945160000},"page":"361-364","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of verapamil and inspired CO2 on the bronchoconstriction provoked by hyperventilation in normal humans"],"prefix":"10.1042","volume":"69","author":[{"given":"C. H. C.","family":"Twort","sequence":"first","affiliation":[{"name":"Department of Medicine, St Thomas's Hospital Medical School, (United Medical and Dental Schools), London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. E.","family":"Neild","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Thomas's Hospital Medical School, (United Medical and Dental Schools), London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. R.","family":"Cameron","sequence":"additional","affiliation":[{"name":"Department of Medicine, St Thomas's Hospital Medical School, (United Medical and Dental Schools), London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/69\/3\/361\/456532\/cs0690361.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/69\/3\/361\/456532\/cs0690361.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:38:03Z","timestamp":1638477483000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/69\/3\/361\/73608\/The-effect-of-verapamil-and-inspired-CO2-on-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0690361","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9,1]]}}}