{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T15:54:42Z","timestamp":1775836482225,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,9,1]]},"abstract":"<jats:p>1. The effects of naloxone (8 mg) on the pressor and plasma catecholamine response to a standard cold-pressor test have been evaluated in six normal male subjects. Plasma catecholamines were estimated by high performance liquid chromatography coupled to electrochemical detection.<\/jats:p>\n               <jats:p>2. Cold stimulation induced significant elevations in plasma noradrenaline and adrenaline to reach mean peak levels 61% and 108% above their respective basal levels (P &amp;lt; 0.05). Systolic blood pressure increased by 23 \u00b1 6.5 mmHg (P &amp;lt; 0.001), and heart rate increased by 7.5 \u00b1 2.5 beats\/min (P &amp;lt; 0.001).<\/jats:p>\n               <jats:p>3. Naloxone pretreatment significantly enhanced the plasma adrenaline response to the cold stimulus by 98% (P &amp;lt; 0.01) with concomitant changes in peak systolic blood pressure (peak increment 31 \u00b1 6 mmHg) and pulse rate (12.5 \u00b1 3.5 beats\/min) responses (both P &amp;lt; 0.05). The mean plasma noradrenaline response to cold also increased after naloxone, but this failed to achieve significance.<\/jats:p>\n               <jats:p>4. Endogenous opioids are likely to be involved in the sympathoadrenal response to a mild acute stress in man.<\/jats:p>","DOI":"10.1042\/cs0690365","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:59:20Z","timestamp":1438945160000},"page":"365-368","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Enhancement of the sympathoadrenal response to the cold-pressor test by naloxone in man"],"prefix":"10.1042","volume":"69","author":[{"given":"Pierre-Marc","family":"Bouloux","sequence":"first","affiliation":[{"name":"Department of Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Grossman","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad","family":"Al-Damluji","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Bailey","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Besser","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/69\/3\/365\/456534\/cs0690365.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/69\/3\/365\/456534\/cs0690365.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:38:05Z","timestamp":1638477485000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/69\/3\/365\/73611\/Enhancement-of-the-sympathoadrenal-response-to-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1985,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0690365","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,9,1]]}}}