{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T02:29:20Z","timestamp":1769308160129,"version":"3.49.0"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,11,1]]},"abstract":"<jats:p>1. We have bred a strain of pigs with an inherited condition of hypocalcaemic rickets, transmitted by an autosomal-recessive mechanism.<\/jats:p>\n               <jats:p>2. Homozygous (affected) piglets grew at half the rate of their heterozygous (clinically normal) littermates, and developed profound hypocalcaemia with severe secondary hyperparathyroidism and hypophosphataemia by 8 weeks of age.<\/jats:p>\n               <jats:p>3. In the hypocalcaemic piglets, plasma 1,25-dihydroxyvitamin D levels were low or undetectable, and 24,25-dihydroxyvitamin D3 levels were also reduced despite 25-hydroxyvitamin D3 levels being 2-fold higher.<\/jats:p>\n               <jats:p>4. There was no detectable 25-hydroxyvitamin D3-1- or -24-hydroxylase enzyme activity in renal homogenates prepared from affected animals.<\/jats:p>\n               <jats:p>5. Plasma and intestinal calcium-binding protein levels were reduced in the hypocalcaemic piglets.<\/jats:p>\n               <jats:p>6. Sucrose density gradient analysis of intestinal cytosol, prepared in high-salt buffer, revealed the presence of a similar amount of a specific &amp;lt;4.2S 1,25-dihydroxyvitamin D3 binder in both groups of piglets.<\/jats:p>\n               <jats:p>7. Administration of pharmacological doses of vitamin D3 to affected animals reversed the hypocalcaemia.<\/jats:p>\n               <jats:p>8. We conclude that this strain of pigs has vitamin D-dependent rickets type I.<\/jats:p>","DOI":"10.1042\/cs0690541","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:59:20Z","timestamp":1438945160000},"page":"541-548","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Vitamin D-dependent rickets type I in pigs"],"prefix":"10.1042","volume":"69","author":[{"given":"John","family":"Fox","sequence":"first","affiliation":[{"name":"Department of Animal Physiology and Nutrition, University of Leeds, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni M. W.","family":"Maunder","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Nutrition, University of Leeds, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie A.","family":"Randall","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, University of Leeds, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony D.","family":"Care","sequence":"additional","affiliation":[{"name":"Department of Animal Physiology and Nutrition, University of Leeds, Leeds, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/69\/5\/541\/456285\/cs0690541.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/69\/5\/541\/456285\/cs0690541.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:40:41Z","timestamp":1638477641000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/69\/5\/541\/73836\/Vitamin-D-dependent-rickets-type-I-in-pigs"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1985,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0690541","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11,1]]}}}