{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:21:15Z","timestamp":1761513675321},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,12,1]]},"abstract":"<jats:p>1. In six patients with hypertriglyceridaemia presenting whilst receiving treatment with \u03b2-adrenoreceptor blocking drugs (mean serum triglycerides 31.2 mmol\/l) the half-life (t1\/2) of an intravenously administered triglyceride emulsion was 32.8 \u00b1 7.9 min (mean \u00b1 sem) on \u03b2-blocker and 22.8 \u00b1 4.8 min after stopping \u03b2-blocker treatment.<\/jats:p>\n               <jats:p>2. In three of these patients subsequent administration of a \u03b2-blocker with intrinsic sympathomimetic activity had no effect on t1\/2.<\/jats:p>\n               <jats:p>3. In a cross-over trial of placebo, atenolol (\u03b21-blocker), propranolol (\u03b21- and \u03b22-blocker) and pindolol (\u03b21- and \u03b22-blocker with intrinsic sympathomimetic activity) in 11 normal men t1\/2 was 11.8\u00b10.9, 12.6\u00b11.1, 14.3\u00b11.7 and 12.4\u00b11.1 min respectively. None of the apparent differences achieved statistical significance, but in two men marked increases in t1\/2 occurred on propranolol.<\/jats:p>\n               <jats:p>4. The concentrations of serum triglycerides and very low density lipoprotein cholesterol in the normal men were, however, increased by \u03b2-blockade, most markedly by pindolol.<\/jats:p>\n               <jats:p>5. Serum high density lipoprotein (HDL) cholesterol concentration decreased in normal men on \u03b2-blockers, most clearly on atenolol and propranolol. This decrease was due to a reduction in cholesterol in the HDL2 subfraction.<\/jats:p>\n               <jats:p>6. No statistically significant effects on serum low density lipoprotein cholesterol or apolipoprotein B concentrations occurred in the normal men.<\/jats:p>\n               <jats:p>7. The doses of atenolol and propranolol used in this study were equipotent as judged by the heart rate response to exercise.<\/jats:p>","DOI":"10.1042\/cs0690713","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T10:59:20Z","timestamp":1438945160000},"page":"713-719","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Short-term effects of <i>\u03b2<\/i>-adrenoceptor blocking drugs with and without cardioselectivity and intrinsic sympathomimetic activity on lipoprotein metabolism in hypertriglyceridaemic patients and in normal men"],"prefix":"10.1042","volume":"69","author":[{"given":"P. N.","family":"Durrington","sequence":"first","affiliation":[{"name":"University of Manchester Departments of Medicine and Cardiology, Manchester Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. C.","family":"Brownlee","sequence":"additional","affiliation":[{"name":"University of Manchester Departments of Medicine and Cardiology, Manchester Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. M.","family":"Large","sequence":"additional","affiliation":[{"name":"University of Manchester Departments of Medicine and Cardiology, Manchester Royal Infirmary, Manchester, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/69\/6\/713\/456386\/cs0690713.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/69\/6\/713\/456386\/cs0690713.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:39:05Z","timestamp":1638477545000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/69\/6\/713\/73676\/Short-term-effects-of-adrenoceptor-blocking-drugs"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1985,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0690713","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,12,1]]}}}