{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T03:10:56Z","timestamp":1648696256476},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,1,1]]},"abstract":"<jats:p>1. Kinins have been considered to be involved in the escape from the sodium retaining effects of mineralocorticoids. In a metabolic study in rats, the importance of the kallikrein-kinin system for sodium and potassium excretion was evaluated by aprotinin-induced kallikrein inhibition under basal conditions and during DOCA administration.<\/jats:p>\n               <jats:p>2. Kallikrein inhibition was accompanied by a transient sodium retention. The escape from the sodium retaining effect of DOCA was not affected. However, the DOCA-induced potassium loss was enhanced.<\/jats:p>\n               <jats:p>3. Kallikrein inhibition decreased urinary prostaglandin (PG) E2 and prevented the DOCA-induced rise in PGE2. Plasma renin activity was stimulated after 10 days of aprotinin administration.<\/jats:p>\n               <jats:p>4. The kallikrein-kinin system is not an important mediator of the escape phenomenon but it may play a role in the regulation of sodium and potassium excretion.<\/jats:p>","DOI":"10.1042\/cs0700013","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:04:05Z","timestamp":1438945445000},"page":"13-17","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mineralocorticoid escape during kallikrein inhibition"],"prefix":"10.1042","volume":"70","author":[{"given":"Axel","family":"Overlack","sequence":"first","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evita","family":"B\u00e4cker-Kreutz","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christa","family":"Ressel","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Michael","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Kolloch","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus-O.","family":"Stumpe","sequence":"additional","affiliation":[{"name":"Medizinische Universit\u00e4ts-Poliklinik, Bonn, West Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/70\/1\/13\/456438\/cs0700013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/70\/1\/13\/456438\/cs0700013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:40:29Z","timestamp":1638477629000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/70\/1\/13\/73816\/Mineralocorticoid-escape-during-kallikrein"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0700013","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1,1]]}}}