{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T10:06:02Z","timestamp":1742637962753},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,2,1]]},"abstract":"<jats:p>1. In the present study, deoxycorticosterone (DOC) and salt was administered to Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) by using silicone-rubber implants (DOC acetate, 100 mg\/kg) and 0.9% NaCl as drinking water. SHR treated with DOC-salt for 4 weeks showed the characteristics of malignant hypertension including marked increases in blood pressure and left ventricular weight with typical histological changes in the kidney.<\/jats:p>\n               <jats:p>2. DOC-salt treatment increased plasma vasopressin levels in WKY (from 6.1 \u00b1 0.5 to 8.9 \u00b1 0.8 pmol\/l) but significantly more in SHR (from 5.0 \u00b1 0.6 to 15.8 \u00b11.2 pmol\/l).<\/jats:p>\n               <jats:p>3. Intravenous administration of the specific antagonist to the pressor effect of vasopressin, d(CH2)5Tyr(Me)AVP (10\u03bcg\/kg), decreased mean arterial pressure of DOC-salt treated WKY and SHR by 6.6 \u00b1 0.9mmHg (P &amp;lt; 0.05) and 9.7 \u00b1 1.7 mmHg (P &amp;lt; 0.05) respectively.<\/jats:p>\n               <jats:p>4. DOC-water treatment also increased plasma AVP levels in SHR to 10.5 \u00b1 0.8 pmol\/l, but the vasopressin antagonist had little effect on blood pressure in these rats.<\/jats:p>\n               <jats:p>5. Plasma levels of vasopressin were significantly correlated with both mean arterial pressure (r = 0.64) and left ventricular weight (r = 0.74). This suggests a close relationship between plasma AVP and severity of hypertension.<\/jats:p>\n               <jats:p>6. The results of the present experiment demonstrate that vasopressin is part of the overall pressor mechanism which contributes to the maintenance of blood pressure in DOC-salt induced malignant hypertension in SHR, but the small fall in pressure produced by the AVP antagonists suggests that the contribution is of only minor importance.<\/jats:p>","DOI":"10.1042\/cs0700191","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:04:05Z","timestamp":1438945445000},"page":"191-198","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Contribution of Vasopressin to the maintenance of blood pressure in deoxycorticosterone-salt induced malignant hypertension in spontaneously hypertensive rats"],"prefix":"10.1042","volume":"70","author":[{"given":"Masao","family":"Hiwatari","sequence":"first","affiliation":[{"name":"Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine M.","family":"Abrahams","sequence":"additional","affiliation":[{"name":"Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Saito","sequence":"additional","affiliation":[{"name":"Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin I.","family":"Johnston","sequence":"additional","affiliation":[{"name":"Monash University Department of Medicine, Prince Henry's Hospital, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/70\/2\/191\/456886\/cs0700191.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/70\/2\/191\/456886\/cs0700191.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:39:29Z","timestamp":1638477569000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/70\/2\/191\/73723\/Contribution-of-Vasopressin-to-the-maintenance-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0700191","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,2,1]]}}}