{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T03:02:50Z","timestamp":1648609370566},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,7,1]]},"abstract":"<jats:p>1. The agglutinating properties of a crude gluten digest, purified gliadin fractions and established plant lectins were investigated using mammalian erythrocytes, rat enterocytes and normal and coeliac human enterocytes as the target systems.<\/jats:p>\n               <jats:p>2. Gliadin preparations failed to cause agglutination of any of the cells tested, whereas established pure plant lectins were active cell agglutinins.<\/jats:p>\n               <jats:p>3. These studies indicate that gliadin peptides do not interact with intestinal cells in a polyvalent, lectin-like manner and as such cannot be regarded as true lectins.<\/jats:p>\n               <jats:p>4. Mucosal damage in coeliac disease is unlikely therefore to be related to lectin-like activity of gliadin.<\/jats:p>","DOI":"10.1042\/cs0710105","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:07:31Z","timestamp":1438945651000},"page":"105-110","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Reappraisal of the \u2018lectin hypothesis' in the aetiopathogenesis of coeliac disease"],"prefix":"10.1042","volume":"71","author":[{"given":"J.","family":"Colyer","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J. G.","family":"Farthing","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. D.","family":"Ohannesian","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chelsea College (University of London), London"},{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. M.","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Chelsea College (University of London), London"},{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/71\/1\/105\/457054\/cs0710105.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/71\/1\/105\/457054\/cs0710105.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:42:39Z","timestamp":1638477759000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/71\/1\/105\/74022\/Reappraisal-of-the-lectin-hypothesis-in-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,7,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0710105","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7,1]]}}}