{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:18:27Z","timestamp":1776485907840,"version":"3.51.2"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,8,1]]},"abstract":"<jats:p>1. The blood pressure (BP) and heart rate (HR) responses to 5 min incremental intravenous infusions of noradrenaline (NA) and arginine vasopressin (AVP) were investigated both in patients with progressive autonomic failure (PAF) and in normal volunteers.<\/jats:p>\n               <jats:p>2. Stepwise infusion of NA at rates of 300\u20133000 pmol min\u22121 kg\u22121 produced a bradycardia and a dose related increase in BP in normal subjects. In subjects with PAF there was no significant HR response but the dose-BP response was shifted to the left with significant pressor responses at infusion rates of 60\u2013300 pmol min\u22121 kg\u22121.<\/jats:p>\n               <jats:p>3. Stepwise infusion of AVP at 0.2\u20135.0 pmol min\u22121 kg\u22121 caused transient bradycardia but no pressor response in seven normal volunteers. Further increases in AVP infusion in three other subjects achieved plasma AVP levels as high as 3000\u20134000 pmol\/l, and still no significant pressor response was observed.<\/jats:p>\n               <jats:p>4. Stepwise infusion of AVP at 0.05\u20132.0 pmol min\u22121 kg\u22121 in the eight subjects with PAF resulted in a pressor response without any change in HR. During this infusion plasma AVP increased from 0.8 \u00b1 0.2 (mean \u00b1 se) to 30 \u00b1 2 pmol\/l. A significant pressor response was already apparent at a plasma AVP level of 5.5 \u00b1 1.8 pmol\/l.<\/jats:p>","DOI":"10.1042\/cs0710173","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:07:31Z","timestamp":1438945651000},"page":"173-178","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Pressor effect of arginine vasopressin in progressive autonomic failure"],"prefix":"10.1042","volume":"71","author":[{"given":"T. D. M.","family":"Williams","sequence":"first","affiliation":[{"name":"Medical Unit, Charing Cross and Westminster Medical School, Westminster Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"DaCosta","sequence":"additional","affiliation":[{"name":"Medical Unit, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Mathias","sequence":"additional","affiliation":[{"name":"Medical Unit, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Bannister","sequence":"additional","affiliation":[{"name":"Department of Neurology, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. L.","family":"Lightman","sequence":"additional","affiliation":[{"name":"Medical Unit, Charing Cross and Westminster Medical School, Westminster Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/71\/2\/173\/457135\/cs0710173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/71\/2\/173\/457135\/cs0710173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:41:19Z","timestamp":1638477679000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/71\/2\/173\/73891\/Pressor-effect-of-arginine-vasopressin-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986,8,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0710173","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,8,1]]}}}