{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T10:59:01Z","timestamp":1758279541941},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,9,1]]},"abstract":"<jats:p>1. Tumour extracts from two patients with humoral hypercalcaemia of malignancy contained material which stimulated adenylate cyclase in chick renal membranes and in rat osteosarcoma cells.<\/jats:p>\n               <jats:p>2. Adenylate cyclase-stimulating activity in each system was inhibited by a specific parathyroid hormone (PTH) antagonist.<\/jats:p>\n               <jats:p>3. Studies in two HPLC systems suggested that the adenylate cyclase-stimulating factors extracted from these tumours differed from each other and from synthetic human parathyroid hormone 1\u201334.<\/jats:p>\n               <jats:p>4. The presence of similar PTH-like adenylate cyclase stimulating material(s) in oncogenic osteomalacia suggests that adenylate cyclase stimulating factor(s) may not be the direct or the sole cause of hypercalcaemia.<\/jats:p>","DOI":"10.1042\/cs0710261","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:07:31Z","timestamp":1438945651000},"page":"261-269","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Humoral hypercalcaemia of malignancy: Report of two further patients with biochemical studies on tumour extracts"],"prefix":"10.1042","volume":"71","author":[{"given":"M. S.","family":"Seshadri","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S.","family":"Mason","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Cornish","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. M.","family":"Pryke","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Posen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Royal North Shore Hospital, St Leonards, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/71\/3\/261\/457438\/cs0710261.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/71\/3\/261\/457438\/cs0710261.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:41:50Z","timestamp":1638477710000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/71\/3\/261\/73950\/Humoral-hypercalcaemia-of-malignancy-Report-of-two"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,9,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1986,9,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0710261","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,9,1]]}}}