{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T14:11:52Z","timestamp":1791727912698,"version":"4.3.4"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,12,1]]},"abstract":"<jats:p>1. Physiological elevation of plasma vasopressin in man results in a small reduction in skeletal muscle blood flow but the action on skin blood flow has not been reported.<\/jats:p>\n               <jats:p>2. We have studied eight male subjects during infusion of arginine vasopressin (AVP) at 2 units\/h for 90 min. Plasma levels of AVP, measured by radioimmunoassay, rose to 68.5 (7.0) pg\/ml, mean (sem). Forearm and finger blood flow was measured with an electronic plethysmograph, hand interdigital skin-fold blood flow with a laser-Doppler blood flow meter and facial temperature with a thermocouple.<\/jats:p>\n               <jats:p>3. All subjects developed marked facial pallor during infusion of AVP, facial temperature falling from 34.2 (0.2) to 32.7 (0.1)\u00b0C (P &amp;lt; 0.001) then rising to 33.7 (0.1)\u00b0C (P &amp;lt; 0.01) after AVP was stopped. Hand interdigital skin-fold blood flow also fell from 2.6 (0.02) to 2.3 (0.02) V (P &amp;lt; 0.001) and rose sharply to 3.6 (0.2) V (P &amp;lt; 0.001) on stopping the infusion. There were small changes in forearm and finger blood flow: both rose, from 6.3 (0.1) to 6.9 (0.1) (P &amp;lt; 0.001) and 46.1 (1.0) to 54.3 (0.7) ml min\u22121 100 ml\u22121 (P &amp;lt; 0.001) respectively. Neither fell when AVP was stopped. Heart rate remained unchanged throughout.<\/jats:p>\n               <jats:p>4. These results indicate that high physiological levels of AVP, comparable with those attained during physical stress, produced a fall in blood flow in the face and interdigital skin-fold of the hand consistent with a fall in nutritional blood flow to skin. Blood flow to skeletal muscle, however, remained little changed whereas that through arteriovenous anastomoses in skin of the finger rose.<\/jats:p>\n               <jats:p>5. We conclude that AVP has a selective vasoactive effect in skin, constricting nutritional blood vessels and venules while promoting an increase in arteriovenous shunting of blood.<\/jats:p>","DOI":"10.1042\/cs0710633","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:07:31Z","timestamp":1438945651000},"page":"633-638","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The differential effect of arginine vasopressin on skin blood flow in man"],"prefix":"10.1042","volume":"71","author":[{"given":"P. G.","family":"Wiles","sequence":"first","affiliation":[{"name":"University Department of Medicine, The General Infirmary, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. J.","family":"Grant","sequence":"additional","affiliation":[{"name":"University Department of Medicine, The General Infirmary, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Davies","sequence":"additional","affiliation":[{"name":"University Department of Medicine, The General Infirmary, Leeds, U.K."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/71\/6\/633\/457369\/cs0710633.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/71\/6\/633\/457369\/cs0710633.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:42:04Z","timestamp":1638477724000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/71\/6\/633\/73960\/The-differential-effect-of-arginine-vasopressin-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1986,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0710633","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,12,1]]}}}