{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:25:02Z","timestamp":1791347102538,"version":"4.3.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"1","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,1,1]]},"abstract":"<jats:p>1. \u00f4-Aminolaevulinic acid (ALA) was determined by g.l.c. with electron-capture detection. Normal plasma level was 92 nmol\/l (sd = 39, n = 89, range 24\u2013270 nmol\/l).<\/jats:p>\n                  <jats:p>2. ALA was undetectable in 35 of 53 samples of normal cerebrospinal fluid (limit of assay 2 nmol\/l). The mean of the other 18 samples was 19 nmol\/l (sd = 10, range 6\u201336 nmol\/l).<\/jats:p>\n                  <jats:p>3. Salivary ALA was generally only 10\u201330% of the plasma level in normal and porphyric subjects.<\/jats:p>\n                  <jats:p>4. Erythrocytes of normal and porphyric subjects contained no detectable ALA and were impermeable to its entry.<\/jats:p>\n                  <jats:p>5. ALA clearance correlated closely with that of creatinine, consistent with it being excreted by glomerular filtration with limited tubular reabsorption.<\/jats:p>\n                  <jats:p>6. In chronic renal failure, serum ALA was elevated to a maximum of three to four times the normal, but its urinary excretion was reduced, in keeping with lessened production.<\/jats:p>\n                  <jats:p>7. In two cases of acute intermittent porphyria with overwhelming neuropathy the maximum plasma levels of ALA were 9 and 12 \u03bcmol\/l. Haematin infusion decreased the ALA levels but without obvious clinical benefit. Limited neurological recovery occurred without major reduction in plasma levels of ALA.<\/jats:p>\n                  <jats:p>8. One subject's attack was precipitated by pregnancy. The neonate was apparently normal, despite high levels of ALA in maternal plasma throughout gestation and a high level of ALA in the cord blood.<\/jats:p>\n                  <jats:p>9. The observations described here do not support the view that ALA may be directly neurotoxic.<\/jats:p>","DOI":"10.1042\/cs0720103","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T07:11:45Z","timestamp":1438931505000},"page":"103-112","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["\u03b4-Aminolaevulinic acid in plasma, cerebrospinal fluid, saliva and erythrocytes: Studies in normal, uraemic and porphyric subjects"],"prefix":"10.1042","volume":"72","author":[{"given":"A.","family":"Gorchein","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Webber","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/1\/103\/457615\/cs0720103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/1\/103\/457615\/cs0720103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T15:42:34Z","timestamp":1638459754000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/72\/1\/103\/74015\/Aminolaevulinic-acid-in-plasma-cerebrospinal-fluid"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0720103","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1,1]]}}}