{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T05:58:46Z","timestamp":1759384726918},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,2,1]]},"abstract":"<jats:p>1. Coeliac patients are known to have an expanded bile salt pool which recirculates slowly due, at least in part, to impaired gall bladder contractility. We have investigated the possibility that delayed small bowel transit of chyme and bile may also contribute to this sluggish recycling.<\/jats:p>\n               <jats:p>2. Plasma cholylglycine, total bile acids and cholecystokinin concentrations were measured after a lactulose-labelled test meal whose mouth-caecum transit time (M\u2013C TT) was assessed by the breath hydrogen technique.<\/jats:p>\n               <jats:p>3. Overall there were no significant differences in plasma bile acid profiles between seven healthy controls and a group of 25 coeliac patients. However, when subjects were divided according to their M\u2013C TT, the 10 with the slowest transit were found to have significant elevation of fasting levels when compared with the 10 with the fastest transit, fasting total bile acids being 3.4 \u00b1 1.3 versus 0.7 \u00b1 0.6 \u03bcmol\/l (P &amp;lt; 0.02) and fasting cholylglycine being 0.43 \u00b1 0.17 versus 0.06 \u00b1 0.04 \u03bcmol\/l (P &amp;lt; 0.05) respectively.<\/jats:p>\n               <jats:p>4. Peak bile acid levels did not differ significantly between subjects with fast or slow transit. However, subjects with slow transit were found to have a delay in the return of plasma bile acid levels to fasting levels so that the 4 h postprandial levels were significantly elevated when compared with those observed in the subjects with fast transit (total bile acids 3.6 \u00b1 1.2 versus 0.19 \u00b1 0.1 \u03bcmol\/l and cholylglycine 0.70 \u00b1 0.13 versus 0.24 \u00b1 0.07 \u03bcmol\/l respectively, both P &amp;lt; 0.01).<\/jats:p>\n               <jats:p>5. We conclude that M\u2013C TT is an important variable determining the postprandial plasma bile acid response, which should be considered when comparing different disease groups in whom gut motility may differ.<\/jats:p>","DOI":"10.1042\/cs0720217","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:11:45Z","timestamp":1438945905000},"page":"217-223","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Delayed postprandial plasma bile acid response in coeliac patients with slow mouth\u2013caecum transit"],"prefix":"10.1042","volume":"72","author":[{"given":"R. C.","family":"Spiller","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. F.","family":"Frost","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry, Central Middlesex Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Stewart","sequence":"additional","affiliation":[{"name":"West Middlesex Hospital, Isleworth, Middx., U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. R.","family":"Bloom","sequence":"additional","affiliation":[{"name":"Royal Postgraduate Medical School, Hammersmith Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. B. A.","family":"Silk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Nutrition, Central Middlesex Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/2\/217\/457675\/cs0720217.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/2\/217\/457675\/cs0720217.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:44:23Z","timestamp":1638477863000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/72\/2\/217\/74138\/Delayed-postprandial-plasma-bile-acid-response-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1987,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0720217","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,2,1]]}}}