{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T17:22:23Z","timestamp":1758820943739},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"3","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,3,1]]},"abstract":"<jats:p>1. The response of circulating 1,25-dihydroxyvitamin D [l,25-(OH)2D] to challenge with vitamin D treatment both before and after 7\u201310 days of prednisone therapy (25 mg\/day) was investigated in five anephric subjects, six patients with chronic renal failure (CRF), two patients with vitamin D intoxication and four patients with hypoparathyroidism.<\/jats:p>\n               <jats:p>2. In anephric subjects serum 25-hydroxyvitamin D [25-(OH)D] rose from 58 \u00b1 48 (sd) to 377\u00b1221 (sd) nmol\/l after administration of 150 \u03bcg of 25-(OH)D3 for 1 month. Serum l,25-(OH)2D, which was barely detectable in only two out of five patients under basal conditions, rose to 30 \u00b1 21 pmol\/l after 2 weeks of therapy with 25-(OH)D3, but fell to 10 \u00b1 5 pmol\/l during prednisone treatment.<\/jats:p>\n               <jats:p>3. In CRF patients circulating l,25-(OH)2D rose from 37 \u00b1 24 to 58 \u00b1 24 pmol\/l during 25-(OH)D3 therapy, but fell to 41 \u00b1 31 pmol\/l during prednisone treatment. In two patients with rheumatoid arthritis, hypercalcaemia due to vitamin D intoxication was associated with raised levels of 1,25-(OH)2D (288 and 317 pmol\/l). Administration of prednisore resulted in suppression of l,25-(OH)2D levels (132 and 96 pmol\/l respectively) and reduction of serum calcium to within the normal range.<\/jats:p>\n               <jats:p>4. In the hypoparathyroid patients prednisone therapy did not affect circulating 25-(OH)D levels but serum l,25-(OH)2D fell from 192 \u00b1 42 to 117 \u00b1 23 pmol\/l and serum calcium from 2.41 \u00b1 0.21 to 2.20 \u00b1 0.05 mmol\/l.<\/jats:p>\n               <jats:p>5. These findings indicate that a steroid sensitive extrarenal production of l,25-(OH)2D may occur in all subjects with a threshold serum concentration of the precursor 25-(OH)D.<\/jats:p>","DOI":"10.1042\/cs0720329","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:11:45Z","timestamp":1438945905000},"page":"329-334","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Extrarenal synthesis of 1,25-dihydroxyvitamin D: Sensitivity to glucocorticoid treatment"],"prefix":"10.1042","volume":"72","author":[{"given":"Silvano","family":"Adami","sequence":"first","affiliation":[{"name":"Istituto di Semeiotica Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Graziani","sequence":"additional","affiliation":[{"name":"Divisione di Nefrologia e Dialisi, Pad. Croff, Ospedale Maggiore, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Tartarotti","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Cappelli","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Casati","sequence":"additional","affiliation":[{"name":"Divisione di Nefrologia e Dialisi, Pad. Croff, Ospedale Maggiore, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cantaluppi","sequence":"additional","affiliation":[{"name":"Divisione di Nefrologia e Dialisi, Pad. Croff, Ospedale Maggiore, Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Braga","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Lo","family":"Cascio","sequence":"additional","affiliation":[{"name":"Istituto di Semeiotica Medica, University of Verona, Verona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/3\/329\/457682\/cs0720329.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/3\/329\/457682\/cs0720329.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:43:26Z","timestamp":1638477806000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/72\/3\/329\/74075\/Extrarenal-synthesis-of-1-25-dihydroxyvitamin-D"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1987,3,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0720329","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,3,1]]}}}