{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T03:44:32Z","timestamp":1771645472787,"version":"3.50.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,5,1]]},"abstract":"<jats:p>1. Plasma levels of atrial natriuretic peptide (ANP) were measured by radioimmunoassay in eight normal healthy volunteers before and during mineralocorticoid escape.<\/jats:p>\n               <jats:p>2. Mean plasma ANP on a fixed sodium intake before fludrocortisone was 6.5\u00b1 sem 1.1 pg\/ml. Within 24 h of fludrocortisone administration there was a significant increase in plasma ANP which continued to increase daily reaching a plateau by day 4 (14.9 \u00b1 2.4 pg\/ml) to day 7 (15.1 \u00b1 2.6 pg\/ml).<\/jats:p>\n               <jats:p>3. The rise in plasma ANP was closely related to the amount of sodium retained during the fludrocortisone treatment and the sodium \u2018escape\u2019 occurred by days 4 to 7.<\/jats:p>\n               <jats:p>4. These results support the concept that ANP could play an important hormonal role in overcoming the sodium-retaining effects of mineralocorticoids in man.<\/jats:p>","DOI":"10.1042\/cs0720531","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:11:45Z","timestamp":1438945905000},"page":"531-539","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Changes in the plasma levels of atrial natriuretic peptides during mineralocorticoid escape in man"],"prefix":"10.1042","volume":"72","author":[{"given":"Francesco P.","family":"Cappuccio","sequence":"first","affiliation":[{"name":"Blood Pressure Unit, Department of Medicine, Charing Cross and Westminster Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmala D.","family":"Markandu","sequence":"additional","affiliation":[{"name":"Blood Pressure Unit, Department of Medicine, Charing Cross and Westminster Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin G.","family":"Buckley","sequence":"additional","affiliation":[{"name":"Blood Pressure Unit, Department of Medicine, Charing Cross and Westminster Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe A.","family":"Sagnella","sequence":"additional","affiliation":[{"name":"Blood Pressure Unit, Department of Medicine, Charing Cross and Westminster Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela C.","family":"Shore","sequence":"additional","affiliation":[{"name":"Blood Pressure Unit, Department of Medicine, Charing Cross and Westminster Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham A.","family":"MacGregor","sequence":"additional","affiliation":[{"name":"Blood Pressure Unit, Department of Medicine, Charing Cross and Westminster Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/5\/531\/458094\/cs0720531.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/5\/531\/458094\/cs0720531.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:42:23Z","timestamp":1638477743000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/72\/5\/531\/73998\/Changes-in-the-plasma-levels-of-atrial-natriuretic"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0720531","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5,1]]}}}