{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:10:26Z","timestamp":1759482626262},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,5,1]]},"abstract":"<jats:p>1. The purpose of this study was to evaluate the renal mechanisms which lead to a high urine [K+] in adrenalectomized (ADX) rats devoid of aldosterone.<\/jats:p>\n               <jats:p>2. By dividing the urine [K+] by the urine to plasma osmolality ratio, the [K+] in the cortical collecting duct luminal fluid can be estimated; dividing this value by the plasma [K+] yields an index of the transtubular [K+] gradient (TTKG) in vivo.<\/jats:p>\n               <jats:p>3. The TTKG was close to 7 in aldosterone deficient ADX rats while on a normal K+ diet and fell towards unity when amiloride or a low K+ diet was administered to these rats.<\/jats:p>\n               <jats:p>4. With a longer time on a low K+ diet, the TTKG was less than 1 in ADX rats. This suggests that K+ was reabsorbed in the medullary collecting duct under these conditions.<\/jats:p>\n               <jats:p>5. Hyperkalemia appears to have an \u2018aldosterone-like\u2019 action in the cortical collecting duct in vivo in the absence of aldosterone in ADX rats. This action of hyperkalemia permits normal K+ excretion rates despite the absence of mineralocorticoids.<\/jats:p>","DOI":"10.1042\/cs0720577","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:11:45Z","timestamp":1438945905000},"page":"577-583","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The relationship between the plasma potassium concentration and renal potassium excretion in the adrenalectomized rat"],"prefix":"10.1042","volume":"72","author":[{"given":"M. L.","family":"West","sequence":"first","affiliation":[{"name":"Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Sonnenberg","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Veress","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Halperin","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Physiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/5\/577\/458098\/cs0720577.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/5\/577\/458098\/cs0720577.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:42:24Z","timestamp":1638477744000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/72\/5\/577\/73996\/The-relationship-between-the-plasma-potassium"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0720577","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5,1]]}}}