{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T16:47:23Z","timestamp":1759942043314},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,5,1]]},"abstract":"<jats:p>1. Binding of 125I-crude gluten digest (Frazer's fraction III, FF-III) and 125I-concanavalin A (Con A) to isolated rat enterocytes and of 125I-FF-III to human enterocytes was investigated.<\/jats:p>\n               <jats:p>2. Specific binding of 125I-FF-III to rat enterocytes was observed but binding was not inhibited by any of a range of simple and complex saccharides, although casein and bovine serum albumin displaced FF-III at high concentrations.<\/jats:p>\n               <jats:p>3. Con A also bound to enterocytes in a specific manner and was inhibited by \u03b1-methyl-D-mannoside, confirming a lectin-mediated interaction.<\/jats:p>\n               <jats:p>4. 125I-FF-III exhibited quantitatively similar specific binding to both normal human and coeliac enterocytes.<\/jats:p>\n               <jats:p>5. The primary interaction of gliadin peptides with the enterocyte surface membrane is not lectin-mediated and unlikely to be of fundamental importance in the pathogenesis of coeliac disease.<\/jats:p>","DOI":"10.1042\/cs0720593","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:11:45Z","timestamp":1438945905000},"page":"593-598","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Gliadin binding to rat and human enterocytes"],"prefix":"10.1042","volume":"72","author":[{"given":"J.","family":"Colyer","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. J.","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. M.","family":"Waldron","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Queen Mary's College, University of London, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. L.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J. G.","family":"Farthing","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, St Bartholomew's Hospital, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/5\/593\/458143\/cs0720593.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/72\/5\/593\/458143\/cs0720593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,2]],"date-time":"2021-12-02T20:42:43Z","timestamp":1638477763000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/72\/5\/593\/74025\/Gliadin-binding-to-rat-and-human-enterocytes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,5,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,5,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0720593","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,5,1]]}}}