{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T21:00:53Z","timestamp":1648587653979},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"4","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,10,1]]},"abstract":"<jats:p>1. Cisplatin [6 mg\/kg body weight, in 0.9% (w\/v) NaCl] was injected intraperitoneally as a single dose to two groups of rats (Fischer 344 strain). Two further groups of rats, injected intraperitoneally with an equivalent volume of 0.9% (w\/v) NaCl, were used as controls. The cisplatin-treated rats developed a pronounced polyuria which did not recover during an 18 week observation period.<\/jats:p>\n               <jats:p>2. After 21 weeks, one group of the cisplatin-treated animals received a 6 h infusion of 2.5% d-glucose. Vasopressin (60 \u03bc-units min\u22121 100 g\u22121 body weight) was incorporated into the infusate for the final 2 h. A control group of animals received an identical infusion. One week later the other group of cisplatin-treated rats received a 6 h infusion of 0.9% (w\/v) NaCl. Indomethacin was incorporated into the infusate for 15 min, at 3 h 52.5 min, to deliver a dose of 10 mg\/kg body weight. A control group again received an identical infusion.<\/jats:p>\n               <jats:p>3. Cisplatin did not impair the antidiuretic effect of vasopressin, but it reduced the natriuretic effect of vasopressin, and also impaired the ability of the animals to produce concentrated urine.<\/jats:p>\n               <jats:p>4. Cisplatin did not alter basal PGE2 excretion, or the reduction in PGE2 excretion induced by indomethacin. However, the urine flow in the cisplatin-treated group did not fall after indomethacin, whereas there was a fall in urine flow in the control group.<\/jats:p>","DOI":"10.1042\/cs0730377","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:13:01Z","timestamp":1438945981000},"page":"377-381","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Renal response to vasopressin and indomethacin in cisplatin-treated rats"],"prefix":"10.1042","volume":"73","author":[{"given":"Christopher J.","family":"Lote","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Birmingham, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest S.","family":"Harpur","sequence":"additional","affiliation":[{"name":"MRC Mechanisms of Drug Toxicity Research Group, Department of Pharmaceutical Sciences, Aston University, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Thewles","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Birmingham, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna J.","family":"Phipps","sequence":"additional","affiliation":[{"name":"MRC Mechanisms of Drug Toxicity Research Group, Department of Pharmaceutical Sciences, Aston University, Birmingham, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/73\/4\/377\/458355\/cs0730377.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/73\/4\/377\/458355\/cs0730377.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:22:28Z","timestamp":1638397348000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/73\/4\/377\/74252\/Renal-response-to-vasopressin-and-indomethacin-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,10,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,10,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0730377","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,10,1]]}}}