{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:59:03Z","timestamp":1762271943769},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"5","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,11,1]]},"abstract":"<jats:p>1. The role of the endothelium in mediating relaxation to acetylcholine, the calcium ionophore A23187, vasoactive intestinal peptide and peptide histidine methionine was studied using isolated human blood vessels.<\/jats:p>\n               <jats:p>2. Segments of renal, colic, pulmonary, uterine, transverse cervical, brachial, coronary and coeliac branch arteries, and saphenous veins, were obtained from surgical resection material for use in tissue bath studies.<\/jats:p>\n               <jats:p>3. Acetylcholine or A23187 produced endothelium-dependent relaxation in isolated vessels from all vascular beds studied. Coronary arteries, however, differed in their response to acetylcholine which produced predominantly a contractile response, either alone or after initial relaxation.<\/jats:p>\n               <jats:p>4. Vasoactive intestinal peptide and peptide histidine methionine produced endothelium-dependent relaxation in coeliac branch arteries. However, these peptides relaxed isolated pulmonary arteries independently of endothelium.<\/jats:p>\n               <jats:p>5. Endothelium-dependent relaxation in response to acetylcholine and A23187 was antagonized by nordihydroguaretic acid, a lipoxygenase inhibitor, and methylene blue and haemoglobin, inhibitors of soluble guanylate cyclase. In these respects the endothelium-dependent responses of human arteries to acetylcholine and A23187 resemble those described in other species.<\/jats:p>","DOI":"10.1042\/cs0730547","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:13:01Z","timestamp":1438945981000},"page":"547-552","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Endothelium-dependent relaxation in isolated human arteries and veins"],"prefix":"10.1042","volume":"73","author":[{"given":"S.","family":"Thom","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. S.","family":"Sever","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/73\/5\/547\/458556\/cs0730547.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/73\/5\/547\/458556\/cs0730547.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:22:23Z","timestamp":1638397343000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/73\/5\/547\/74224\/Endothelium-dependent-relaxation-in-isolated-human"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1987,11,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0730547","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,11,1]]}}}