{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:48:41Z","timestamp":1697176121724},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"6","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,12,1]]},"abstract":"<jats:p>1. The production of prostaglandin (PG) E2, F2\u03b1 and thromboxane B2 (TXB2) by isolated glomeruli, cortical tubular suspensions and medullary and papillary slices was measured in normal Long\u2013Evans rats 4, 8 and 14 days after starting on oral Na+ load and the results were compared with those of rats on a normal Na+ intake.<\/jats:p>\n               <jats:p>2. In glomeruli, PGE2 decreased at days 4 and 8, and returned to normal at 14 days. PGF2\u03b1 decreased only at day 4 and TXB2 decreased in all Na+-loaded animals. In cortical suspensions, a transient decrease of PGE2 was observed at day 4. In medullary slices, PGE2 and TXB2 decreased in all experimental periods. In contrast, in papillae, a significant increase of PGE2 was observed with Na+ loading at day 8, but PGF2\u03b1 and TXB2 did not change consistently.<\/jats:p>\n               <jats:p>3. Similar changes were observed in rats with hypothalamic diabetes insipidus (DI rats) Na+ loaded for 4 days, as compared with DI rats on a normal Na+ intake.<\/jats:p>\n               <jats:p>4. The results suggest that prostanoids participate in the renal adaptation to an increased Na+ intake, and that this response is relatively independent of the presence of antidiuretic hormone.<\/jats:p>","DOI":"10.1042\/cs0730653","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:13:01Z","timestamp":1438945981000},"page":"653-657","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of sodium loading on the renal synthesis of prostanoids in the rat"],"prefix":"10.1042","volume":"73","author":[{"given":"M.","family":"Rathaus","sequence":"first","affiliation":[{"name":"Department of Nephrology, Meir Hospital, Kfar Saba, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Podjarny","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Meir Hospital, Kfar Saba, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Meir Hospital, Kfar Saba, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Kariv","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Meir Hospital, Kfar Saba, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Bernheim","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Meir Hospital, Kfar Saba, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/73\/6\/653\/458642\/cs0730653.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/73\/6\/653\/458642\/cs0730653.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:23:02Z","timestamp":1638397382000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/73\/6\/653\/74290\/Effects-of-sodium-loading-on-the-renal-synthesis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,12,1]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1987,12,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0730653","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,12,1]]}}}