{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:36:57Z","timestamp":1760549817595},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,2,1]]},"abstract":"<jats:p>1. Measurements of the rate of lithium clearance, which provides an estimate of proximal renal tubular iso-osmotic reabsorption (i.e. sodium and H2O), were used to study H2O and electrolyte reabsorption during the development of cyclosporin A (CsA) induced nephrotoxicity.<\/jats:p>\n               <jats:p>2. CsA, administered daily by gavage at 50 mg\/kg body weight, produced a nephrotoxicity which was characterized by reductions in the clearance rates of creatinine, sodium and potassium, and increased glycosuria, enzymuria and urine flow rate.<\/jats:p>\n               <jats:p>3. Decreased lithium clearance rate and increased proximal iso-osmotic reabsorption accompanied significant reductions in creatinine clearance rate. Absolute proximal tubular reabsorption, however, was not affected by CsA administration.<\/jats:p>\n               <jats:p>4. Reductions in the absolute distal tubular reabsorption of sodium, potassium and H2O were also observed.<\/jats:p>\n               <jats:p>5. Alterations in renal tubular function occur early in the development of CsA nephrotoxicity as a result of both direct proximal tubulotoxicity and an effect on the afferent arteriole.<\/jats:p>\n               <jats:p>6. Measurements of the rate of lithium clearance may be a useful adjunct to the diagnosis of CsA nephrotoxicity.<\/jats:p>","DOI":"10.1042\/cs0740173","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:18:52Z","timestamp":1438946332000},"page":"173-178","update-policy":"http:\/\/dx.doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Lithium clearance measurements as an indication of cyclosporin a nephrotoxicity in the rat"],"prefix":"10.1042","volume":"74","author":[{"given":"P. H.","family":"Whiting","sequence":"first","affiliation":[{"name":"1Department of Chemical Pathology, University of Aberdeen, Aberdeen, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Aberdeen, Aberdeen, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/2\/173\/458729\/cs0740173.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/2\/173\/458729\/cs0740173.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:23:55Z","timestamp":1638397435000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/74\/2\/173\/74337\/Lithium-clearance-measurements-as-an-indication-of"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0740173","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2,1]]}}}