{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:23:27Z","timestamp":1780485807164,"version":"3.54.1"},"reference-count":0,"publisher":"Portland Press Ltd.","issue":"2","content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,2,1]]},"abstract":"<jats:p>1. The effect of a \u03b1-human atrial natriuretic peptide (1\u201328) (ANP) on human vasculature was investigated in vivo and in vitro. Possible involvement of vascular dopamine receptors and the renin-angiotensin system in the response to ANP was also studied in vivo.<\/jats:p>\n               <jats:p>2. Forearm blood blow was measured by venous occlusion plethysmography. Isolated human blood vessels were studied using conventional organ bath techniques.<\/jats:p>\n               <jats:p>3. ANP (0.1\u20131 \u03bcg\/min, intra-arterially) produced a dose-dependent increase in forearm blood flow, corresponding to a 163% increase in net forearm blood flow in the study arm. This action of ANP was not antagonized by (R)-sulpiride (100 \u03bcg\/min, intra-arterially), a selective vascular dopamine receptor antagonist, or 50 mg of oral captopril, an inhibitor of angiotensin-converting enzyme.<\/jats:p>\n               <jats:p>4. ANP (1 nmol\/l\u20131 \u03bcmol\/l) produced concentration-dependent relaxation of isolated human arteries, including brachial artery, but was without effect on isolated human saphenous vein.<\/jats:p>\n               <jats:p>5. ANP produces vasodilatation in vivo and relaxes isolated human arterial smooth muscle. This action of ANP may contribute to its reported hypotensive effects in vivo.<\/jats:p>","DOI":"10.1042\/cs0740207","type":"journal-article","created":{"date-parts":[[2015,8,7]],"date-time":"2015-08-07T11:18:52Z","timestamp":1438946332000},"page":"207-211","update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Direct effect of <i>\u03b1<\/i>-human atrial natriuretic peptide on human vasculature <i>in vivo<\/i> and <i>in vitro<\/i>"],"prefix":"10.1042","volume":"74","author":[{"given":"A.","family":"Hughes","sequence":"first","affiliation":[{"name":"1Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Thom","sequence":"additional","affiliation":[{"name":"2Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Goldberg","sequence":"additional","affiliation":[{"name":"3Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Martin","sequence":"additional","affiliation":[{"name":"4Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sever","sequence":"additional","affiliation":[{"name":"5Department of Clinical Pharmacology, St Mary's Hospital Medical School, London"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","container-title":["Clinical Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/2\/207\/458755\/cs0740207.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/clinsci\/article-pdf\/74\/2\/207\/458755\/cs0740207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T22:24:29Z","timestamp":1638397469000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/clinsci\/article\/74\/2\/207\/74368\/Direct-effect-of-human-atrial-natriuretic-peptide"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,2,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1988,2,1]]}},"URL":"https:\/\/doi.org\/10.1042\/cs0740207","relation":{},"ISSN":["0143-5221","1470-8736"],"issn-type":[{"value":"0143-5221","type":"print"},{"value":"1470-8736","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,2,1]]}}}